{"id":"W2060357887","doi":"10.1007/s10689-014-9744-1","title":"High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry","year":2014,"lang":"en","type":"article","venue":"Familial Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"Lynch syndrome; MSH6; MSH2; Medicine; MLH1; Microsatellite instability; Germline mutation; Prostate cancer; Oncology; Cancer; Internal medicine; Prostate; DNA mismatch repair; Gene mutation; Colorectal cancer; Mutation; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006526008,0.0004091617,0.0007266334,0.0001387849,0.00008973416,0.00001448804,0.0003732704,0.000260789,0.0001584157],"category_scores_gemma":[0.0005399125,0.0003411434,0.0002116835,0.0008552074,0.0004118728,0.0001044369,0.00009080342,0.0005475785,0.000004516336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002178718,"about_ca_system_score_gemma":0.001778241,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2138231,"about_ca_topic_score_gemma":0.05941255,"domain_scores_codex":[0.9962928,0.0002934065,0.0009612037,0.0009389799,0.0008531598,0.0006604075],"domain_scores_gemma":[0.9977989,0.0004393235,0.0004252293,0.0008805667,0.0002907682,0.0001652816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002372729,0.0001525966,0.9138498,0.001091129,0.0001025585,0.0001073319,0.008506803,0.02092647,0.04047872,0.0000249499,0.008034779,0.004352137],"study_design_scores_gemma":[0.004105375,0.0005244061,0.970873,0.001226978,0.0002076659,0.000004976011,0.001487382,0.003484617,0.01615812,0.0002837972,0.001201651,0.0004420221],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863132,0.008338844,0.00002324117,0.0006575774,0.001859122,0.001772059,0.0005856678,0.000131986,0.0003182638],"genre_scores_gemma":[0.9924322,0.003425721,0.0008774328,0.001135867,0.0003339642,0.001328348,0.00004398876,0.00006702622,0.0003553958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1544105,"threshold_uncertainty_score":0.999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384205891857165,"score_gpt":0.2705002169015311,"score_spread":0.2566581579829595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}