{"id":"W2060361484","doi":"10.1021/bi800439t","title":"Interactions between the Three CIN85 SH3 Domains and Ubiquitin: Implications for CIN85 Ubiquitination","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Ubiquitin; SH3 domain; Cell biology; Endocytosis; Ubiquitin ligase; Signal transducing adaptor protein; Chemistry; Plasma protein binding; Biology; Phosphorylation; Biochemistry; Receptor; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087398,0.0001386558,0.0001040161,0.00001877737,0.0003750187,0.0000193047,0.0001503079,0.0001355964,0.00001446379],"category_scores_gemma":[0.00003676791,0.0001209286,0.0001009694,0.00006527247,0.0001509126,0.000005476397,0.00004061058,0.0000888344,0.000002013497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001667099,"about_ca_system_score_gemma":0.00005914134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009587808,"about_ca_topic_score_gemma":0.00003174767,"domain_scores_codex":[0.9992297,0.00001031116,0.000197497,0.0003101689,0.0000691536,0.0001832149],"domain_scores_gemma":[0.9993698,0.00003443409,0.00008294164,0.0003343215,0.0001060682,0.00007244255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002418222,0.00002651295,0.02104642,0.00002781448,0.00004078168,3.755026e-7,0.00003952439,0.000001229001,0.976511,0.0001818204,0.0009243214,0.001176026],"study_design_scores_gemma":[0.0006679053,0.00009280274,0.1672095,0.00001687842,0.00008136802,0.00008003764,0.00009689944,0.00004296546,0.779002,0.0005615314,0.05185322,0.0002948633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9521654,0.0004267625,0.04411443,0.001704317,0.00005455749,0.0002672668,0.0001443534,0.00002288765,0.001100066],"genre_scores_gemma":[0.9938176,0.0001349057,0.0004050012,0.000121039,0.0006432594,0.0001128898,0.004146146,0.00002004662,0.0005990944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.197509,"threshold_uncertainty_score":0.4931327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343194627373742,"score_gpt":0.2660122055517856,"score_spread":0.2425802592780481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}