{"id":"W2060415058","doi":"10.1016/j.transproceed.2007.03.049","title":"Optimization of Immunosuppressive Drug Monitoring in Children","year":2007,"lang":"en","type":"article","venue":"Transplantation Proceedings","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Western Ontario; Western University","funders":"","keywords":"Sirolimus; Pharmacology; Pharmacokinetics; Drug; Tacrolimus; CYP3A4; Therapeutic drug monitoring; Medicine; Drug metabolism; Dosing; Metabolite; Drug interaction; Toxicity; Mycophenolic acid; Calcineurin; Cytochrome P450; Metabolism; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006955966,0.0003067626,0.0004964955,0.000535753,0.0003764067,0.0006098066,0.0002725984,0.0002797244,0.0007531788],"category_scores_gemma":[0.003478581,0.0001080383,0.0002392969,0.0005493281,0.0002213425,0.0003904056,0.0003281979,0.0005945038,0.0001217011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001009868,"about_ca_system_score_gemma":0.001777291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00359033,"about_ca_topic_score_gemma":0.004860454,"domain_scores_codex":[0.9993131,0.0002993161,0.00007617264,0.00005497959,0.0001648193,0.00009161085],"domain_scores_gemma":[0.9990048,0.0003181513,0.0003295117,0.00003323107,0.0001427316,0.0001715919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008649903,0.0003568899,0.8261653,0.0002138061,0.00008945012,0.002535641,0.0004845567,0.002534448,0.003376191,0.0009101286,0.003628053,0.1588406],"study_design_scores_gemma":[0.0001360191,0.002381397,0.9325185,0.0004670805,0.0003507342,0.01560991,0.001407527,0.005585953,0.01824403,0.001246998,0.02200778,0.00004405497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735906,0.01025433,0.003962886,0.002893151,0.0001020602,0.0000659155,0.000261873,0.00007882014,0.008790486],"genre_scores_gemma":[0.9905791,0.003097059,0.005339343,0.0002350782,0.00007496302,0.00004875602,0.0001396812,0.00001674614,0.0004691668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00359033,"threshold_uncertainty_score":0.007327139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00954691065669033,"score_gpt":0.2746913406181418,"score_spread":0.2651444299614514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}