{"id":"W2060415058","doi":"10.1016/j.transproceed.2007.03.049","title":"Optimization of Immunosuppressive Drug Monitoring in Children","year":2007,"lang":"en","type":"article","venue":"Transplantation Proceedings","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Western Ontario; Western University","funders":"","keywords":"Sirolimus; Pharmacology; Pharmacokinetics; Drug; Tacrolimus; CYP3A4; Therapeutic drug monitoring; Medicine; Drug metabolism; Dosing; Metabolite; Drug interaction; Toxicity; Mycophenolic acid; Calcineurin; Cytochrome P450; Metabolism; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545019,0.0001132387,0.0001888609,0.0002496835,0.00002868068,0.000008507547,0.00004590427,0.00005343944,0.00002789719],"category_scores_gemma":[0.000005730334,0.0001022467,0.00005499068,0.0002850142,0.00002520148,0.000208163,0.000001949422,0.00009279951,0.000003449272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003631745,"about_ca_system_score_gemma":0.00001761664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006669643,"about_ca_topic_score_gemma":0.000001522247,"domain_scores_codex":[0.9990746,0.000003213299,0.0003742673,0.0001581122,0.0002267152,0.0001631114],"domain_scores_gemma":[0.9996513,0.00002989964,0.0001103741,0.00004215154,0.0001102093,0.00005612894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005734948,0.0001107792,0.9876019,0.0003136652,0.00006052903,0.0000152141,0.002117605,0.0004593179,0.008138206,0.000197579,0.000001136766,0.0004105584],"study_design_scores_gemma":[0.002917031,0.00005872451,0.8272958,0.0005579671,0.0001134041,0.0001211906,0.0002026756,0.00006973155,0.1685698,0.00001780478,8.760346e-7,0.00007494826],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943954,0.00008516985,0.002539076,0.0000387195,0.00004788082,0.000383731,0.00001171165,0.00003737762,0.002460893],"genre_scores_gemma":[0.99151,0.0005714291,0.007645837,0.00001762173,0.00003012314,0.000009552408,0.00009208675,0.00001524217,0.0001081157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1604316,"threshold_uncertainty_score":0.4169498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00954691065669033,"score_gpt":0.2746913406181418,"score_spread":0.2651444299614514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}