{"id":"W2060426314","doi":"10.1021/bi2003795","title":"Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Western Canada Research Grid; University of Alberta; Canadian Light Source; Howard Hughes Medical Institute","keywords":"Missense mutation; Phosphopeptide; Peptide; Binding site; Plasma protein binding; Genetics; Mutation; DNA; Chemistry; Biology; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002671115,0.0004780242,0.0003898325,0.0001962609,0.0002190303,0.0003373718,0.0003017747,0.000584838,0.002302472],"category_scores_gemma":[0.0003496157,0.0002257633,0.0003169091,0.0001623683,0.0004887303,0.0001718969,0.0002445756,0.0005587789,0.0003814319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003000025,"about_ca_system_score_gemma":0.0002272324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001488155,"about_ca_topic_score_gemma":0.001567315,"domain_scores_codex":[0.9996721,0.00007943391,0.00003653592,0.00005772925,0.00008624107,0.00006790036],"domain_scores_gemma":[0.9997523,0.00009002125,0.00005883083,0.00002029909,0.00001631811,0.00006213335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001746196,0.0003362581,0.001405879,0.00004273852,0.00006559289,0.0009667726,0.00003170383,0.0009073383,0.9913173,0.0001540254,0.0001712486,0.002855001],"study_design_scores_gemma":[0.0001966565,0.003508753,0.01742133,0.00001989618,0.0001736602,0.003297417,0.00009106673,0.003188437,0.9694006,0.0001715509,0.002499174,0.00003143145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983608,0.0003710768,0.0002367307,0.00005048167,0.00002070711,0.00001125795,0.0002430589,0.00002227321,0.0006836432],"genre_scores_gemma":[0.9989974,0.000167038,0.000231536,0.00005085841,0.000004498341,0.000005005338,0.0001581425,0.00002358478,0.0003618677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002302472,"threshold_uncertainty_score":0.007702529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02729382304066965,"score_gpt":0.2539753717279212,"score_spread":0.2266815486872516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}