{"id":"W2060426314","doi":"10.1021/bi2003795","title":"Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Western Canada Research Grid; University of Alberta; Canadian Light Source; Howard Hughes Medical Institute","keywords":"Missense mutation; Phosphopeptide; Peptide; Binding site; Plasma protein binding; Genetics; Mutation; DNA; Chemistry; Biology; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140618,0.0001850889,0.0001449692,0.00002648724,0.00005872305,0.000007584058,0.0001711483,0.0002249896,0.0003619322],"category_scores_gemma":[0.0001043198,0.0001681427,0.0002293926,0.00007664308,0.00009608252,0.000002748329,0.00003700092,0.00006720617,0.00004863889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002585126,"about_ca_system_score_gemma":0.0001141048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007443221,"about_ca_topic_score_gemma":0.000002295075,"domain_scores_codex":[0.9991021,0.00003361469,0.0002138415,0.0003248153,0.0001127646,0.0002128372],"domain_scores_gemma":[0.9992065,0.000009861666,0.0001238578,0.0004634328,0.0000863317,0.000109964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003025447,0.0001734841,0.0003054802,0.00001886458,0.00009438844,0.000008281982,0.00003356528,9.612274e-7,0.9960393,0.00003200542,0.0007375933,0.002253524],"study_design_scores_gemma":[0.0003364535,0.0003428592,0.001145995,0.00004868686,0.00002094359,0.00003858489,0.00003903101,9.131329e-7,0.9970564,0.0004253607,0.0003355154,0.0002092915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851081,0.0002646852,0.000358159,0.000009881072,0.0000628355,0.0001279713,0.0001091574,0.00001635978,0.01394281],"genre_scores_gemma":[0.9964426,0.00008391842,0.002592388,0.00003815352,0.0001186751,0.00002365623,0.0001643703,0.00002137436,0.0005148284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01342798,"threshold_uncertainty_score":0.685666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02729382304066965,"score_gpt":0.2539753717279212,"score_spread":0.2266815486872516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}