{"id":"W2060457614","doi":"10.1016/j.jaci.2009.07.003","title":"Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency","year":2009,"lang":"en","type":"letter","venue":"Journal of Allergy and Clinical Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; SickKids Foundation; University of Toronto; University of Ottawa; Hospital for Sick Children","funders":"","keywords":"Adenosine deaminase; Adenosine deaminase deficiency; Polyethylene glycol; Adenosine; Medicine; Liver disease; AMP deaminase; Gastroenterology; Internal medicine; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005657886,0.0007504312,0.001339627,0.0002295599,0.0005020021,0.0004707952,0.0004859533,0.005673654,0.001414278],"category_scores_gemma":[0.001965636,0.0002341948,0.0006612262,0.0001590432,0.0006709005,0.0005853871,0.0002675741,0.003616039,0.0006183178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008591224,"about_ca_system_score_gemma":0.0002646576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000660698,"about_ca_topic_score_gemma":0.00072537,"domain_scores_codex":[0.9997248,0.00009353136,0.00004014107,0.00003431598,0.00004732328,0.00005983102],"domain_scores_gemma":[0.9991261,0.000586434,0.00005078267,0.00006120759,0.00006352612,0.0001119852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02165537,0.001572722,0.01269285,0.0007175757,0.0004126822,0.5933759,0.0003378878,0.001539383,0.09417487,0.006054935,0.1254692,0.1419967],"study_design_scores_gemma":[0.019967,0.019574,0.06344689,0.000487693,0.00152184,0.472873,0.0003627242,0.01818997,0.1368014,0.01401555,0.2524236,0.0003364416],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5424225,0.01221413,0.006522062,0.3808525,0.02659557,0.0002970607,0.0006258084,0.0008615286,0.02960881],"genre_scores_gemma":[0.9003693,0.003605824,0.002235192,0.06967906,0.01078365,0.0001103296,0.0001773137,0.00008888711,0.01295035],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.005673654,"threshold_uncertainty_score":0.006233454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.016448400788434,"score_gpt":0.2802206017491173,"score_spread":0.2637722009606833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}