{"id":"W2060469824","doi":"10.1021/bi4010039","title":"Quinine Binding by the Cocaine-Binding Aptamer. Thermodynamic and Hydrodynamic Analysis of High-Affinity Binding of an Off-Target Ligand","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Australian Research Council; Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; York University","keywords":"Aptamer; Chemistry; Ligand (biochemistry); Isothermal titration calorimetry; Quinine; Small-angle X-ray scattering; Binding site; Allosteric regulation; Stereochemistry; Crystallography; Biophysics; Biochemistry; Biology; Scattering; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713309,0.0002034815,0.0002341733,0.0001034838,0.0001312759,0.000195609,0.0002031235,0.0002619947,0.000790801],"category_scores_gemma":[0.0003749752,0.000113161,0.0001795838,0.00007879474,0.0002008658,0.0001559934,0.0001236258,0.0003338089,0.000260526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003681807,"about_ca_system_score_gemma":0.000113842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009362837,"about_ca_topic_score_gemma":0.001147879,"domain_scores_codex":[0.9997804,0.00003834452,0.00000801752,0.00004753271,0.00009786135,0.00002796127],"domain_scores_gemma":[0.9998145,0.00005721871,0.00004503981,0.00001375734,0.00003551523,0.00003405657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000308442,0.00001162816,0.0003214186,0.00001011656,0.000003320883,0.00001470371,0.000009338552,0.0002110266,0.9987311,0.00003399651,0.00001405572,0.0006084305],"study_design_scores_gemma":[0.0000049634,0.00008099285,0.004739714,0.000001765462,0.000003999475,0.0001165989,0.000008581436,0.007121433,0.9875287,0.00003834562,0.0003485897,0.000006319274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932153,0.0003322835,0.005606314,0.00004002815,0.000009851151,0.00001543956,0.00008508335,0.0000530381,0.0006426319],"genre_scores_gemma":[0.9957124,0.0001332304,0.00320015,0.00003622611,0.000003964008,0.00001441574,0.0001671469,0.00001726731,0.0007151858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009362837,"threshold_uncertainty_score":0.002671301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004796664416188445,"score_gpt":0.2378537174619554,"score_spread":0.2330570530457669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}