{"id":"W2060471476","doi":"10.1074/jbc.m005474200","title":"Retinoblastoma Gene Promoter Directs Transgene Expression Exclusively to the Nervous System","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; University Health Network","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Biology; Transgene; Molecular biology; Genetically modified mouse; Retinoblastoma; Promoter; Gene; Regulation of gene expression; Locus control region; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982762,0.0004441335,0.000415338,0.0003843168,0.000281294,0.0003807008,0.0005001051,0.0002845206,0.00282465],"category_scores_gemma":[0.0001431091,0.0003805486,0.0003548448,0.000220924,0.000450462,0.0001927892,0.0004103569,0.00089314,0.003125575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003157363,"about_ca_system_score_gemma":0.0006399478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009634863,"about_ca_topic_score_gemma":0.00204574,"domain_scores_codex":[0.9997752,0.00002198461,0.00001589802,0.00007198775,0.00008121805,0.00003384662],"domain_scores_gemma":[0.9998434,0.00003052172,0.00004570928,0.00003115565,0.00001707056,0.00003227168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003518539,0.00001720106,0.00009200491,0.00004153176,0.000003529536,0.000033211,0.00002558522,0.00003329894,0.9970606,0.0003346168,0.0000751866,0.00224798],"study_design_scores_gemma":[0.00002367485,0.0001216494,0.001147971,0.00002021832,0.00002089546,0.0003193278,0.00001749154,0.000419033,0.982648,0.00009671614,0.01515859,0.00000660955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.809682,0.005158714,0.1584478,0.0004601134,0.0003714779,0.000745098,0.003985982,0.002698812,0.01845003],"genre_scores_gemma":[0.8025043,0.006618428,0.1402881,0.000231075,0.00007749239,0.0006218718,0.007884029,0.0005235256,0.04125113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00282465,"threshold_uncertainty_score":0.009449422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02190841195173017,"score_gpt":0.2506749599202874,"score_spread":0.2287665479685572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}