{"id":"W2060471476","doi":"10.1074/jbc.m005474200","title":"Retinoblastoma Gene Promoter Directs Transgene Expression Exclusively to the Nervous System","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; University Health Network","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Biology; Transgene; Molecular biology; Genetically modified mouse; Retinoblastoma; Promoter; Gene; Regulation of gene expression; Locus control region; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003360014,0.0001749705,0.0003745529,0.00002733719,0.00007505426,0.00001544376,0.0002325566,0.0002559325,0.0001507265],"category_scores_gemma":[0.0001990478,0.00009030003,0.000248364,0.0001899049,0.00005522527,0.00002108548,0.00005888887,0.0004702549,0.00002061303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811271,"about_ca_system_score_gemma":0.00008762693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001554585,"about_ca_topic_score_gemma":2.315011e-7,"domain_scores_codex":[0.9986619,0.00005978089,0.0004718835,0.0002105863,0.0003324553,0.0002634168],"domain_scores_gemma":[0.998957,0.00004392627,0.0002456134,0.0002547222,0.0002015276,0.0002971855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008503086,0.00009300812,0.0001848124,0.00005697901,0.00004461273,0.001054056,0.00008683452,0.00005155349,0.9935654,4.85358e-7,0.001049154,0.002962741],"study_design_scores_gemma":[0.0009040898,0.0005577996,0.002355311,0.0004973671,0.00005944298,0.008198991,0.0001024745,0.00003100974,0.9673039,0.00000437599,0.01986722,0.0001180404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935644,0.0008857253,0.001448332,0.00188856,0.0001650701,0.0002174286,0.000006615399,0.00003952702,0.001784347],"genre_scores_gemma":[0.9974359,0.0001321504,0.0009493635,0.0003396455,0.0008737215,0.000008784689,0.000004447721,0.00001656886,0.0002394097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02626157,"threshold_uncertainty_score":0.3682328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02190841195173017,"score_gpt":0.2506749599202874,"score_spread":0.2287665479685572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}