{"id":"W2060486960","doi":"10.1158/1535-7163.targ-09-b223","title":"Abstract B223: Protein kinase C iota as a target for glioblastoma therapy","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Lamellipodium; Motility; Cancer research; MARCKS; Mitosis; Protein kinase C; Biology; Cell growth; Cell biology; Small hairpin RNA; Cell; Cancer; Cancer cell; Filopodia; Pseudopodia; Kinase; Cell migration; Actin; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128139,0.000462585,0.0003942534,0.0005579702,0.0002214305,0.0005368103,0.0002628173,0.0006417649,0.01435201],"category_scores_gemma":[0.00009939991,0.0001057736,0.0002583491,0.0004283438,0.0001416639,0.0001981914,0.0002526939,0.0009214003,0.004492398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007851584,"about_ca_system_score_gemma":0.0006189776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008914881,"about_ca_topic_score_gemma":0.001269369,"domain_scores_codex":[0.9999431,0.000009543719,0.000004408128,0.000006235896,0.00002177162,0.00001481022],"domain_scores_gemma":[0.9999555,0.000003439017,0.000007807139,0.000002745759,0.000009365618,0.00002106625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00572052,0.001835064,0.001815599,0.002209218,0.0001137831,0.001684558,0.00004162813,0.0009341224,0.4451513,0.00622454,0.1845744,0.3496954],"study_design_scores_gemma":[0.002974691,0.007685394,0.03044861,0.0006225383,0.0003158813,0.005964427,0.00008632494,0.003335936,0.29309,0.003225094,0.6521801,0.0000711199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.45237,0.2859071,0.00767005,0.03212517,0.01426229,0.001571907,0.007362827,0.001784463,0.1969463],"genre_scores_gemma":[0.7473633,0.121162,0.007519196,0.00529288,0.002352606,0.0007013823,0.009866507,0.0001518248,0.1055904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01435201,"threshold_uncertainty_score":0.04801232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011961650146183,"score_gpt":0.2911181703607663,"score_spread":0.2709985538593044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}