{"id":"W2060639379","doi":"10.1021/cn2000926","title":"Aβ(1-42) Assembly in the Presence of <i>scyllo</i>-Inositol Derivatives: Identification of an Oxime Linkage as Important for the Development of Assembly Inhibitors","year":2011,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Oxime; Fibrillogenesis; Stereochemistry; Lead compound; Combinatorial chemistry; Inositol; In vitro; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006710925,0.0001307095,0.0002254745,0.00006926359,0.0000745297,0.00001214342,0.0005732464,0.00005242271,0.000002920282],"category_scores_gemma":[0.00099075,0.00007579839,0.00007173842,0.0005110535,0.0004674044,0.000212047,0.0000982561,0.000129605,0.000001168975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002044257,"about_ca_system_score_gemma":0.000331765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003742347,"about_ca_topic_score_gemma":0.00000295136,"domain_scores_codex":[0.9979427,0.00007011738,0.0006641229,0.0003337344,0.0007194426,0.0002698662],"domain_scores_gemma":[0.9984987,0.000389807,0.0003309825,0.0004767014,0.0001846525,0.0001191493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001856151,0.001001429,0.01302689,0.00007519902,0.00004710317,0.000008071492,0.001426754,4.212986e-7,0.9836164,0.0001090062,0.00001925207,0.0004838612],"study_design_scores_gemma":[0.0004638976,0.0002419507,0.1064047,0.00006017193,0.00005499538,0.000006630878,0.0003676298,0.0002815825,0.8919114,0.0001391806,0.00001038093,0.00005747767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985032,0.000181163,0.0001523432,0.000131026,0.00004226976,0.0008785835,0.00001405601,0.000008323298,0.00008904055],"genre_scores_gemma":[0.9989645,0.00003244664,0.0007758608,0.00007678116,0.00001392114,0.0001119608,0.000008459933,0.00000958515,0.000006424052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09337783,"threshold_uncertainty_score":0.3090969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05610718784613822,"score_gpt":0.3363727301935717,"score_spread":0.2802655423474335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}