{"id":"W2060640014","doi":"10.1016/j.cbpc.2007.05.006","title":"Aryl hydrocarbon receptor signaling in rainbow trout hepatocytes: Role of hsp90 and the proteasome","year":2007,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"University of Waterloo","keywords":"Aryl hydrocarbon receptor; Geldanamycin; Hsp90; Rainbow trout; Trout; Heat shock protein; Cytochrome P450; Biology; Proteasome inhibitor; Chemistry; Proteasome; Cell biology; Molecular biology; Endocrinology; Biochemistry; Gene; Metabolism; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162724,0.0001684019,0.0001595896,0.0001924261,0.0002379804,0.000438696,0.0001019903,0.0001782346,0.00136849],"category_scores_gemma":[0.00007616012,0.0001368484,0.0002741542,0.0001554275,0.000211451,0.0004107589,0.0001947444,0.0002786079,0.0003194825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004720978,"about_ca_system_score_gemma":0.0004161651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002863233,"about_ca_topic_score_gemma":0.004601438,"domain_scores_codex":[0.9999276,0.000006964364,0.000004353095,0.00001346866,0.00001588068,0.0000317085],"domain_scores_gemma":[0.9999431,0.000002992413,0.00001276768,0.000007696875,0.00001264339,0.00002079703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004800625,0.00002921024,0.002293886,0.00003640179,0.00003133281,0.0001002056,0.00004028438,0.0001403002,0.9930711,0.0005254685,0.0002120947,0.0030396],"study_design_scores_gemma":[0.00008820567,0.0006514241,0.3407072,0.00001733993,0.00009628163,0.00118188,0.0004680709,0.002379116,0.6477559,0.000805139,0.005820791,0.00002873516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933657,0.002836046,0.001023597,0.0002648313,0.00002640373,0.000005771057,0.0002820564,0.00004554956,0.002150062],"genre_scores_gemma":[0.9949194,0.00092846,0.0003041582,0.00004327165,0.00001071906,0.000004829924,0.0002831338,0.000008329482,0.003497781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002863233,"threshold_uncertainty_score":0.005693138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440843691671357,"score_gpt":0.2780401481424339,"score_spread":0.2636317112257203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}