{"id":"W2060745251","doi":"10.1002/jps.21036","title":"Polymeric Micellar Delivery Reduces Kidney Distribution and Nephrotoxic Effects of Cyclosporine A After Multiple Dosing","year":2007,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Nephrotoxicity; Renal function; Chemistry; Kidney; Pharmacology; Creatinine; Micelle; Pharmacokinetics; Ethylene oxide; Urea; Saline; Medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003364843,0.0005150931,0.0006727509,0.000495288,0.0002648533,0.0004404322,0.0004451516,0.0005423778,0.001504942],"category_scores_gemma":[0.0004425653,0.0003064624,0.000516706,0.0003089274,0.0004060509,0.000753769,0.0002482126,0.001397201,0.0003227841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000509073,"about_ca_system_score_gemma":0.0005832404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00109603,"about_ca_topic_score_gemma":0.001540583,"domain_scores_codex":[0.9996426,0.00004953698,0.00001726729,0.00006592184,0.00007861503,0.0001460154],"domain_scores_gemma":[0.999521,0.00009263365,0.000162127,0.00005512192,0.00003567669,0.0001334894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003178826,0.000515126,0.0001827923,0.00003907521,0.00003403663,0.00007209927,0.00002604855,0.0003545782,0.9910032,0.00007368612,0.0001022627,0.004418398],"study_design_scores_gemma":[0.0001331001,0.004704616,0.001888904,0.000004773983,0.00006556923,0.0002299146,0.00001633035,0.001318157,0.9910919,0.00003175232,0.000505037,0.000009830137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973286,0.0006471887,0.001349101,0.00005210059,0.00004616931,0.00001898891,0.00004946796,0.00008838183,0.0004200958],"genre_scores_gemma":[0.9969964,0.000360504,0.000752877,0.00003135949,0.00003341105,0.00001597525,0.0001152605,0.00003557195,0.001658662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504942,"threshold_uncertainty_score":0.005034506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027721618828971,"score_gpt":0.3423286485636437,"score_spread":0.322051432375354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}