{"id":"W2060757466","doi":"10.1523/jneurosci.2126-08.2008","title":"Huntingtin Modulates Transcription, Occupies Gene Promoters<i>In Vivo</i>, and Binds Directly to DNA in a Polyglutamine-Dependent Manner","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Dalhousie University; National Institutes of Health; Glendorn Foundation; Massachusetts General Hospital","keywords":"Huntingtin; Chromatin immunoprecipitation; Promoter; Transcription factor; Biology; Molecular biology; Transcription (linguistics); Mutant; Chromatin; Exon; Gene expression; Gene; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009898419,0.0001714775,0.000134549,0.0001228261,0.0001127576,0.000295703,0.0001479573,0.0001422987,0.0008937219],"category_scores_gemma":[0.0001515292,0.0001360579,0.0001212696,0.0000795215,0.0002375487,0.0001345211,0.0001443368,0.0002386427,0.0003111832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053041,"about_ca_system_score_gemma":0.0001269006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006356288,"about_ca_topic_score_gemma":0.001870255,"domain_scores_codex":[0.999861,0.00002443651,0.000006493656,0.00005175933,0.00003452996,0.00002179584],"domain_scores_gemma":[0.9999025,0.0000289129,0.00002309091,0.00001147542,0.00001575166,0.00001824117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000332224,0.000007527983,0.000661285,0.00001602621,0.000004390715,0.00002812188,0.00001495389,0.00002665102,0.9981299,0.00005574853,0.00002188595,0.001000364],"study_design_scores_gemma":[0.00001451854,0.00025562,0.06684996,0.00002395471,0.00003193457,0.000488728,0.00009990556,0.001212511,0.927507,0.000286908,0.003221556,0.000007372705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922721,0.002536483,0.003017754,0.00008335154,0.00002552434,0.000006104864,0.0001955201,0.00005541724,0.001807705],"genre_scores_gemma":[0.9955433,0.0009958636,0.00133214,0.00006538222,0.00001373802,0.000009527024,0.0004797021,0.00001566235,0.001544763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008937219,"threshold_uncertainty_score":0.002989769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03132933440646526,"score_gpt":0.257204914122157,"score_spread":0.2258755797156917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}