{"id":"W2060763507","doi":"10.4161/cbt.9.11.11882","title":"MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity","year":2010,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Bortezomib; Mdm2; Proteasome inhibitor; Proteasome; Pharmacology; Cancer research; Apoptosis; Multiple myeloma; Viability assay; Chemistry; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007593517,0.0002363437,0.0005005765,0.0003286125,0.00009867799,0.0002524275,0.0001997943,0.0001760389,0.001019902],"category_scores_gemma":[0.00008497328,0.00009647023,0.000217921,0.0002125233,0.0001177463,0.0001368893,0.0001890414,0.0004169424,0.0001995612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001751472,"about_ca_system_score_gemma":0.0001713402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003161372,"about_ca_topic_score_gemma":0.001346484,"domain_scores_codex":[0.999927,0.00001424527,0.000007181507,0.0000136814,0.00002008941,0.00001775754],"domain_scores_gemma":[0.9999747,0.000004818167,0.000004880907,0.000003171823,0.000003445797,0.000008937094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001417744,0.0003426987,0.0004585782,0.0003024474,0.00007677853,0.0001657828,0.00002147385,0.0004296172,0.9769637,0.0002092981,0.0006124784,0.01899951],"study_design_scores_gemma":[0.0003720857,0.004801611,0.008268214,0.0000212557,0.0001618583,0.0008684794,0.00003601088,0.001402749,0.9678967,0.0001290999,0.01602436,0.00001746247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854902,0.007568148,0.001592098,0.0002653603,0.00009501872,0.00008536973,0.0006535049,0.0001959724,0.004054163],"genre_scores_gemma":[0.9931259,0.002874638,0.00119927,0.0001013937,0.0000182357,0.00004624801,0.0006165996,0.00001140767,0.00200628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019902,"threshold_uncertainty_score":0.003411889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758960195250794,"score_gpt":0.3042208287082948,"score_spread":0.2866312267557869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}