{"id":"W2060795231","doi":"10.1016/j.freeradbiomed.2011.01.038","title":"A critical life-supporting role for cystathionine γ-lyase in the absence of dietary cysteine supply","year":2011,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakehead University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cysteine; Cystathionine beta synthase; Glutathione; Homocysteine; Internal medicine; Methionine; Transsulfuration; Chemistry; Endocrinology; Biochemistry; Cystathionine gamma-lyase; Cysteine metabolism; Biology; Amino acid; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001292114,0.0001275096,0.0004611302,0.0001334483,0.00006669638,0.000001522836,0.0001907308,0.0001764308,0.0002330527],"category_scores_gemma":[0.005858156,0.00006792992,0.00005433862,0.0001836451,0.001437295,0.00003716242,0.00005991872,0.00034596,0.000002940315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008509352,"about_ca_system_score_gemma":0.00009357239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003930809,"about_ca_topic_score_gemma":0.00004716819,"domain_scores_codex":[0.9986106,0.0001159533,0.0004639129,0.0002561252,0.0001647236,0.0003886662],"domain_scores_gemma":[0.9984332,0.000886797,0.00005606634,0.0002968466,0.00009477037,0.0002323503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01123233,0.003213387,0.4099523,0.002739587,0.0004958838,0.001673098,0.02077483,2.266894e-7,0.3440333,0.0973026,0.02669981,0.08188268],"study_design_scores_gemma":[0.03105649,0.05533119,0.8052948,0.001905182,0.0006414449,0.002002209,0.01093451,0.00323154,0.006240242,0.05699546,0.02568802,0.0006789485],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705477,0.005600103,0.0004091794,0.02013069,0.0001209261,0.0006574742,0.00004894301,0.00001992107,0.00246506],"genre_scores_gemma":[0.9964585,0.0002981965,0.001101768,0.001659822,0.0002801962,0.00004714422,0.00006527935,0.00000855097,0.00008052831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3953425,"threshold_uncertainty_score":0.7013184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05013119745133296,"score_gpt":0.3669043507227984,"score_spread":0.3167731532714655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}