{"id":"W2060797161","doi":"10.1016/j.jconrel.2013.08.012","title":"Effective response of doxorubicin-sensitive and -resistant breast cancer cells to combinational siRNA therapy","year":2013,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions","keywords":"Doxorubicin; Breast cancer; Cancer research; Pharmacology; Chemistry; Cancer; Medicine; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003603058,0.0001240188,0.0003528322,0.0001046952,0.00003552085,0.00002012541,0.00009430937,0.0000747332,0.00004298421],"category_scores_gemma":[0.0001204927,0.00008710288,0.0001588835,0.00005603578,0.00005826116,0.000009721262,0.00002619591,0.00009192479,0.000004063804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002051508,"about_ca_system_score_gemma":0.0001362372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005939872,"about_ca_topic_score_gemma":0.000005811326,"domain_scores_codex":[0.9989827,0.0002459213,0.000347082,0.0001253543,0.0001717667,0.0001271707],"domain_scores_gemma":[0.9983823,0.0001480375,0.0003108684,0.0001045831,0.0009193543,0.0001348671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0334188,0.0001136333,0.0001831102,0.000004744033,0.0003038243,0.0000116904,0.00008129386,0.000125024,0.9590728,0.000008310747,0.001796672,0.004880146],"study_design_scores_gemma":[0.01225294,0.002691317,0.08207934,0.00008422251,0.00005324216,0.00005982944,0.0001617267,0.00008147569,0.901966,0.00005509173,0.0003768249,0.0001379939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968556,0.001173054,0.000167431,0.001152336,0.0001299175,0.0004281374,0.00003457947,0.000001165287,0.00005783077],"genre_scores_gemma":[0.9983443,0.0005783965,0.00005588516,0.0006007465,0.0001342043,0.00002047504,0.000001254034,0.000009882788,0.00025483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08189622,"threshold_uncertainty_score":0.3551953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003513681067439752,"score_gpt":0.2314422771787352,"score_spread":0.2279285961112955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}