{"id":"W2060802768","doi":"10.1186/1471-2202-9-17","title":"Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants","year":2008,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Alzheimer Society; Muscular Dystrophy Association","keywords":"Transmembrane domain; Amyloid precursor protein; Mutant; Transmembrane protein; Chemistry; Peptide; Dimer; Amyloid precursor protein secretase; Mutation; Alzheimer's disease; Biochemistry; Biology; Amino acid; Gene; Medicine; Disease; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978174,0.0001974614,0.0001247724,0.0001245958,0.0001351534,0.0001307956,0.0001031044,0.0001960732,0.0004783474],"category_scores_gemma":[0.0002306452,0.00006756582,0.0001300283,0.0001030987,0.00008114828,0.0000971987,0.00009368281,0.0001536166,0.0001772602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001904008,"about_ca_system_score_gemma":0.00007757072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002151266,"about_ca_topic_score_gemma":0.0001966209,"domain_scores_codex":[0.9998943,0.00003711231,0.00001026254,0.00001789285,0.00002684293,0.00001362759],"domain_scores_gemma":[0.9999285,0.00001271271,0.00002593442,0.000005877818,0.000009933269,0.00001702642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001477744,0.00004734274,0.001409135,0.00002572274,0.00000874098,0.0001249004,0.00002691433,0.0001782577,0.9964191,0.0001215185,0.00008602637,0.001404558],"study_design_scores_gemma":[0.00006508159,0.0007776729,0.04155483,0.00001899985,0.00004531467,0.005116431,0.0001187878,0.005957776,0.9405434,0.0005057847,0.005281467,0.00001444474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975007,0.0007259349,0.001132887,0.00004442622,0.000008366048,0.00001356834,0.00008662527,0.00001277414,0.000474682],"genre_scores_gemma":[0.9983779,0.0002092371,0.0008253704,0.00002717592,0.000003721027,0.0000084487,0.0002211338,0.000002625505,0.0003243851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004783474,"threshold_uncertainty_score":0.001600266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0421302036416988,"score_gpt":0.2885706138044772,"score_spread":0.2464404101627784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}