{"id":"W2060809493","doi":"10.1038/srep08694","title":"Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ministry of Science, ICT and Future Planning; Pohang University of Science and Technology","keywords":"DISC1; Endoplasmic reticulum; Cell biology; Gene knockdown; Calcium signaling; Calcium; Inositol; Biology; Calcium in biology; Receptor; Endocrinology; Signal transduction; Internal medicine; Medicine; Intracellular; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006927436,0.0001555809,0.0001435731,0.0001101653,0.0001133459,0.0001207324,0.00009780588,0.0001363136,0.00001765131],"category_scores_gemma":[0.0001558238,0.0001370546,0.00008163965,0.0002767364,0.0002095216,0.00001302311,0.0001024652,0.00008068902,0.00001950167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005766224,"about_ca_system_score_gemma":0.0001888169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003112262,"about_ca_topic_score_gemma":0.0003258109,"domain_scores_codex":[0.9983087,0.00004980781,0.0003914414,0.0006710268,0.0002997211,0.0002793187],"domain_scores_gemma":[0.9987841,0.000004830615,0.0001665244,0.0007106417,0.0001593212,0.0001746457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005268969,0.0004382367,0.09240235,0.00005562536,0.00007948688,0.0006810621,0.0005659372,0.00450422,0.8118901,0.0007376593,0.08318433,0.004934039],"study_design_scores_gemma":[0.001356875,0.000183179,0.01405038,0.00006191889,0.00003159893,0.001172622,0.0004608122,0.007115434,0.8486974,0.005414278,0.1207729,0.0006825813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893447,0.0002841105,0.0005728495,0.0001805788,0.006752213,0.0001950056,0.000004300083,0.00003315037,0.002633093],"genre_scores_gemma":[0.9885942,0.000004291207,0.0003138951,0.00003336691,0.0001266409,0.00001555782,0.0006174773,0.00001790942,0.01027661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07835197,"threshold_uncertainty_score":0.5588924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132100604645581,"score_gpt":0.2456573612853628,"score_spread":0.2324473008208047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}