{"id":"W2060809493","doi":"10.1038/srep08694","title":"Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ministry of Science, ICT and Future Planning; Pohang University of Science and Technology","keywords":"DISC1; Endoplasmic reticulum; Cell biology; Gene knockdown; Calcium signaling; Calcium; Inositol; Biology; Calcium in biology; Receptor; Endocrinology; Signal transduction; Internal medicine; Medicine; Intracellular; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194394,0.0005415874,0.0002204266,0.0002263571,0.0002792905,0.0003530055,0.0001821779,0.0003255146,0.0008506379],"category_scores_gemma":[0.000125661,0.0001257562,0.0002084987,0.0001405668,0.0003120715,0.0001511852,0.0003105315,0.0004454757,0.0003030436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006189891,"about_ca_system_score_gemma":0.0003168103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009211808,"about_ca_topic_score_gemma":0.001523323,"domain_scores_codex":[0.9999101,0.00001280607,0.000009586587,0.00002288929,0.00002326061,0.00002143722],"domain_scores_gemma":[0.9998975,0.000007762098,0.0000524756,0.000006908278,0.000007886199,0.00002749484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001310469,0.00000843449,0.0008131132,0.00005160665,0.000005256293,0.0002202284,0.00001405927,0.00007940002,0.9974147,0.0001678118,0.00008296084,0.001011348],"study_design_scores_gemma":[0.0000500586,0.0001345114,0.03273566,0.00002345161,0.00004560088,0.001642727,0.00009853369,0.002435912,0.956467,0.0002655302,0.006086066,0.00001493017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908565,0.003528406,0.00294471,0.0002902554,0.00007786493,0.00001927057,0.0009880373,0.0001080658,0.001186845],"genre_scores_gemma":[0.9953369,0.001303878,0.001487415,0.00006890795,0.000006892849,0.00001066578,0.0005303076,0.00001510193,0.001239936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009211808,"threshold_uncertainty_score":0.00449115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132100604645581,"score_gpt":0.2456573612853628,"score_spread":0.2324473008208047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}