{"id":"W2060814375","doi":"10.1038/nature02789","title":"Sirtuin activators mimic caloric restriction and delay ageing in metazoans","year":2004,"lang":"en","type":"article","venue":"Nature","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":1864,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; University of British Columbia; University of Connecticut","keywords":"Sirtuin; Caenorhabditis elegans; Drosophila melanogaster; Biology; Saccharomyces cerevisiae; Caloric theory; Model organism; NAD+ kinase; Ageing; SIRT2; Genetics; Cell biology; Longevity; Fecundity; Resveratrol; Sirtuin 1; Senescence; Melanogaster; Drosophila (subgenus); Yeast; Gene; Biochemistry; Enzyme; Medicine; Population","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581185,0.0002325185,0.0003383319,0.0002149338,0.0001352435,0.0002666965,0.000294587,0.0003935236,0.001268126],"category_scores_gemma":[0.0001786228,0.0002023803,0.0003109868,0.000128888,0.0003407147,0.0002627098,0.0002620346,0.0005595792,0.0002744654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000335423,"about_ca_system_score_gemma":0.0001999967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007997833,"about_ca_topic_score_gemma":0.002208482,"domain_scores_codex":[0.9999337,0.00001492791,0.000005620554,0.00001231529,0.00001633521,0.00001708129],"domain_scores_gemma":[0.9999101,0.00001939564,0.00002400452,0.00002069623,0.000007842094,0.00001800271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006869209,0.0000163826,0.00024185,0.0000629326,0.00002379228,0.00006323196,0.00002945344,0.0001867288,0.9951922,0.0004434822,0.00008544104,0.002967623],"study_design_scores_gemma":[0.00009582203,0.0005858969,0.003571541,0.00001131282,0.00007708789,0.0002003421,0.00006972317,0.0006631903,0.9862062,0.0004938025,0.008015047,0.00001001753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983721,0.006239665,0.005082062,0.0006730283,0.000163094,0.00002498488,0.0003222084,0.0003943791,0.003379411],"genre_scores_gemma":[0.9927007,0.002279941,0.001921447,0.0001423902,0.00001969331,0.00001234622,0.0002298946,0.0000402831,0.00265339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001268126,"threshold_uncertainty_score":0.004242301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007082781368305835,"score_gpt":0.2711072205801067,"score_spread":0.2640244392118009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}