{"id":"W2060818486","doi":"10.1074/jbc.m111.305268","title":"Cell-Cell Membrane Fusion Induced by p15 Fusion-associated Small Transmembrane (FAST) Protein Requires a Novel Fusion Peptide Motif Containing a Myristoylated Polyproline Type II Helix","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Marine Biosciences; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Polyproline helix; Ectodomain; Transmembrane domain; Lipid bilayer fusion; Peptide; Myristoylation; Chemistry; Biophysics; Chinese hamster ovary cell; Transmembrane protein; Peptide sequence; Liposome; Cell membrane; Lipid bilayer; Amino acid; Protein structure; Biochemistry; Membrane; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008141419,0.0004790874,0.0008851304,0.0001052481,0.0003177233,0.00002003019,0.0006108251,0.001241482,0.003158073],"category_scores_gemma":[0.000443035,0.0003384017,0.0003534968,0.0002296673,0.0002291455,0.00009172429,0.0002239215,0.001395153,0.00004663341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267864,"about_ca_system_score_gemma":0.0001767885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001190568,"about_ca_topic_score_gemma":0.000003241672,"domain_scores_codex":[0.9972358,0.0003086981,0.00124374,0.0004264265,0.0001202071,0.0006651271],"domain_scores_gemma":[0.9980004,0.0001570996,0.00103023,0.0002806064,0.0004005364,0.0001311005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01021334,0.001749886,0.0001169964,0.00006617224,0.0001496893,0.0000499514,0.0005988248,8.808138e-7,0.9861924,0.000001756004,0.0003902358,0.0004698454],"study_design_scores_gemma":[0.005161917,0.004098942,0.0005687806,0.0003253678,0.00007990272,0.0002622117,0.0005353199,0.00001034539,0.9867992,0.00001328904,0.001741071,0.0004036758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935923,0.003267584,0.00005716311,0.0001495568,0.000278589,0.0002899716,0.00005904119,0.0000773453,0.002228426],"genre_scores_gemma":[0.9948089,0.0003437102,0.0001594672,0.0001766432,0.00006586336,0.000007004956,0.0001607957,0.00003468989,0.00424293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005051421,"threshold_uncertainty_score":0.9999068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349639384070259,"score_gpt":0.230661869467738,"score_spread":0.1971654756270353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}