{"id":"W2060834185","doi":"10.1083/jcb.153.5.957","title":"Cooh-Terminal Truncations Promote Proteasome-Dependent Degradation of Mature Cystic Fibrosis Transmembrane Conductance Regulator from Post-Golgi Compartments","year":2001,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Proteasome; Cystic fibrosis transmembrane conductance regulator; Cell biology; Proteases; Proteolysis; Protease; Transmembrane protein; Golgi apparatus; Mutant; Lysosome; Transmembrane domain; Biochemistry; Endoplasmic reticulum; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001623418,0.0002086186,0.000196682,0.00009830917,0.0001087982,0.0002748532,0.00009896806,0.0002018902,0.0007531008],"category_scores_gemma":[0.0002530249,0.0001062222,0.000198278,0.00008570364,0.0001680332,0.0001921641,0.0001875469,0.0003170707,0.0006353178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549809,"about_ca_system_score_gemma":0.0001427129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002731976,"about_ca_topic_score_gemma":0.0004503931,"domain_scores_codex":[0.9998893,0.00001992869,0.00001366183,0.00001748287,0.00002667636,0.00003291032],"domain_scores_gemma":[0.9997845,0.00004134712,0.00006181666,0.00003943929,0.00002292652,0.00004996093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001310572,0.00001992848,0.0001980172,0.00002379926,0.000005301974,0.00009550551,0.00001007215,0.00005334167,0.998623,0.0001065375,0.00004167054,0.0006916731],"study_design_scores_gemma":[0.00002461548,0.0002446982,0.006088912,0.00000783969,0.00001146672,0.001128498,0.00003215612,0.00139835,0.9887948,0.0001022529,0.002161128,0.000005272291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970422,0.00119015,0.001017907,0.00006204925,0.00001684805,0.00001127282,0.0001060092,0.00002431385,0.0005291613],"genre_scores_gemma":[0.9974635,0.0005421715,0.0008680446,0.00003884042,0.000008461837,0.00001018108,0.0002348652,0.00001483315,0.0008191981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007531008,"threshold_uncertainty_score":0.002519369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0173851812978871,"score_gpt":0.2946380546905479,"score_spread":0.2772528733926609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}