{"id":"W2060841935","doi":"10.1128/aac.49.12.4860-4866.2005","title":"New Reporter Cell Line To Evaluate the Sequential Emergence of Multiple Human Cytomegalovirus Mutations during In Vitro Drug Exposure","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Foscarnet; Cidofovir; Ganciclovir; Human cytomegalovirus; Virology; Biology; Reporter gene; Cell culture; Mutation; Molecular biology; Virus; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001192719,0.0009325912,0.001233705,0.0006758486,0.0003011709,0.0007032626,0.001224807,0.0008952325,0.001527767],"category_scores_gemma":[0.0005582008,0.0003630589,0.0007880113,0.0005918471,0.0003047579,0.0005927927,0.000695084,0.002356994,0.001375182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004764739,"about_ca_system_score_gemma":0.0004139423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008957009,"about_ca_topic_score_gemma":0.001075884,"domain_scores_codex":[0.9989089,0.0001634045,0.0001954873,0.0002347652,0.0004003076,0.00009710068],"domain_scores_gemma":[0.9993119,0.0001708243,0.00007713383,0.0001269918,0.0002218775,0.00009129207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000847647,0.00009350733,0.0002795698,0.00006193775,0.000009547094,0.00005794016,0.00004986687,0.0001081336,0.9972925,0.0002539298,0.000224793,0.001483589],"study_design_scores_gemma":[0.00003748192,0.000488615,0.0008329828,0.00001020426,0.00002914477,0.0005226631,0.00002652007,0.002852138,0.9884652,0.0000681087,0.006649024,0.00001801571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5982283,0.004817073,0.3791771,0.0007128972,0.001025724,0.001140045,0.008928113,0.001853503,0.004117318],"genre_scores_gemma":[0.690771,0.005317342,0.2610993,0.0005273962,0.0002497243,0.002213279,0.02567285,0.0005399432,0.01360921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527767,"threshold_uncertainty_score":0.006307781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0282408110810469,"score_gpt":0.3241598470956492,"score_spread":0.2959190360146023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}