{"id":"W2060874227","doi":"10.1242/jcs.01142","title":"Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation","year":2004,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"MyoD; Myogenin; Myogenesis; PITX2; Biology; MyoD Protein; Myogenic regulatory factors; Protein kinase B; Psychological repression; Repressor; Molecular biology; Cell biology; Transcription factor; Myocyte; Gene expression; Biochemistry; Gene; Signal transduction; Homeobox","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574442,0.0006039226,0.000449032,0.0002774325,0.0002364296,0.0004429859,0.0003467131,0.0002965206,0.002436917],"category_scores_gemma":[0.0001239718,0.0004359444,0.0003065089,0.000264639,0.0003044484,0.000139465,0.0005644067,0.0006489145,0.001186567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000531781,"about_ca_system_score_gemma":0.0003531975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001605896,"about_ca_topic_score_gemma":0.00386331,"domain_scores_codex":[0.9996907,0.00003759899,0.0000271818,0.00004848898,0.0001284164,0.0000675884],"domain_scores_gemma":[0.999866,0.00002322691,0.00003097197,0.00001380875,0.000009365923,0.00005650486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007438134,0.00002597532,0.0002207125,0.00004342806,0.000008025733,0.00006905685,0.000005782549,0.00004106027,0.9988765,0.00005292465,0.00006204992,0.0005201511],"study_design_scores_gemma":[0.00003551674,0.0001204407,0.009585937,0.0000073333,0.00001683845,0.0004476082,0.00002511369,0.0009282864,0.9833732,0.00003296948,0.005418947,0.000007719227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897285,0.002796078,0.002176914,0.0002072292,0.00006319032,0.0000290835,0.001078348,0.0002064833,0.003714001],"genre_scores_gemma":[0.9843407,0.001124514,0.002251143,0.0001440284,0.00001691712,0.00003271887,0.003447864,0.00007320399,0.008568901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002436917,"threshold_uncertainty_score":0.008152246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004902895145665726,"score_gpt":0.2295580011242786,"score_spread":0.2246551059786129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}