{"id":"W2060874227","doi":"10.1242/jcs.01142","title":"Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation","year":2004,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"MyoD; Myogenin; Myogenesis; PITX2; Biology; MyoD Protein; Myogenic regulatory factors; Protein kinase B; Psychological repression; Repressor; Molecular biology; Cell biology; Transcription factor; Myocyte; Gene expression; Biochemistry; Gene; Signal transduction; Homeobox","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121094,0.00004190952,0.00006753181,0.00004010705,0.00006037395,0.000008844508,0.00007954627,0.0000380698,0.000002617868],"category_scores_gemma":[0.00008181872,0.00003124783,0.00001869842,0.00006259019,0.0001760413,0.00001390639,0.00005466749,0.00004487799,1.710896e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003006167,"about_ca_system_score_gemma":0.00006766576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001952344,"about_ca_topic_score_gemma":0.000001400872,"domain_scores_codex":[0.9995652,0.0000149017,0.0001350097,0.0001086752,0.00009981098,0.00007643255],"domain_scores_gemma":[0.9996429,0.00000486654,0.0001517996,0.00006561761,0.00008563379,0.00004919624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003741539,0.00003866779,0.000558021,0.0000131113,0.000001427115,4.057855e-7,0.00008208206,0.00007225411,0.998412,0.00003371091,0.00001457021,0.0007363793],"study_design_scores_gemma":[0.0004567116,0.0003468652,0.0854815,0.00002542127,0.000005265066,0.00000787752,0.00006154916,0.00001971681,0.9130715,0.0004270477,0.00005734113,0.00003924318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986113,0.0007081121,0.0002133166,0.0001001734,0.00004494513,0.0000313544,5.94917e-7,6.913502e-7,0.0002895494],"genre_scores_gemma":[0.9992061,0.0003590776,0.0003482008,0.00003272775,0.00002566288,3.128675e-7,5.610919e-7,0.000001866249,0.00002547678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08534049,"threshold_uncertainty_score":0.127425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004902895145665726,"score_gpt":0.2295580011242786,"score_spread":0.2246551059786129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}