{"id":"W2060875158","doi":"10.1016/s0014-5793(00)02138-4","title":"Phosphorylation of MYPT1 by protein kinase C attenuates interaction with PP1 catalytic subunit and the 20 kDa light chain of myosin","year":2000,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Myosin light-chain kinase; Protein subunit; Phosphorylation; Immunoglobulin light chain; Chemistry; Myosin; Cell biology; Protein kinase A; Biophysics; Chain (unit); Biochemistry; Biology; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969492,0.0002730508,0.0003281532,0.0001130557,0.0001689853,0.0002179179,0.0002381163,0.0002390358,0.001941595],"category_scores_gemma":[0.0002961985,0.000167145,0.0001496258,0.00009603892,0.0002945982,0.0001847657,0.0001675652,0.0005895455,0.0004322185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615065,"about_ca_system_score_gemma":0.0003043578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005704744,"about_ca_topic_score_gemma":0.0006661177,"domain_scores_codex":[0.9998598,0.00002896645,0.00000778293,0.00001806716,0.0000219316,0.00006350181],"domain_scores_gemma":[0.9998609,0.00003689415,0.00003179356,0.0000136198,0.000009607467,0.00004705824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001181856,0.0001032762,0.0002409255,0.00005048479,0.000006292194,0.0000705016,0.00001564833,0.00004591063,0.9970969,0.00009198852,0.0000516582,0.001044572],"study_design_scores_gemma":[0.0001257951,0.00137765,0.01122923,0.000009188674,0.00001746836,0.0003759339,0.00002949619,0.0007842801,0.9848657,0.00006645072,0.001114147,0.000004764477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978789,0.001045685,0.0002440623,0.0000675458,0.00002358485,0.00001121397,0.00004863031,0.000009933188,0.0006703921],"genre_scores_gemma":[0.9967995,0.0009311482,0.0005591715,0.00004812705,0.00002250056,0.00002431865,0.000163786,0.000007580382,0.001443839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941595,"threshold_uncertainty_score":0.006495297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005083115300516143,"score_gpt":0.2036154665993682,"score_spread":0.1985323512988521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}