{"id":"W2060879405","doi":"10.1093/jac/dkg278","title":"Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations","year":2003,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Health Sciences Centre","funders":"","keywords":"Azithromycin; Streptococcus pneumoniae; Microbiology; Cmax; Pharmacodynamics; Pharmacokinetics; Macrolide Antibiotics; Antibacterial agent; Biology; Pharmacology; Chemistry; Antibiotics; Erythromycin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003303722,0.0003294437,0.0005549354,0.0001577326,0.00006649941,0.0006479893,0.0003783566,0.0005043073,0.0004951837],"category_scores_gemma":[0.001055537,0.0001531646,0.0004271485,0.0001252845,0.0002086196,0.0003164571,0.0002427959,0.0003610963,0.0001438234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004273978,"about_ca_system_score_gemma":0.0004010737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496506,"about_ca_topic_score_gemma":0.0009151825,"domain_scores_codex":[0.9996153,0.0001656005,0.00002243139,0.00005747998,0.00009386244,0.00004533043],"domain_scores_gemma":[0.9994987,0.0003094603,0.00009451219,0.00002320377,0.00004453601,0.00002960491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004570356,0.0002780829,0.00737322,0.0005395021,0.0001745907,0.0002523366,0.0001058134,0.04783712,0.9292556,0.0001760792,0.0001414998,0.009295799],"study_design_scores_gemma":[0.0003075447,0.02113005,0.02932938,0.00005865296,0.0004533636,0.001264038,0.0001638983,0.208944,0.7356647,0.0003538195,0.002235511,0.00009506171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949772,0.0009803022,0.003353861,0.00003601905,0.000006514856,0.00002286915,0.0002237183,0.00003015299,0.0003693833],"genre_scores_gemma":[0.9982116,0.0003525183,0.001126039,0.0000107035,0.000002545674,0.00001476265,0.0001689786,0.00000386342,0.000109028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496506,"threshold_uncertainty_score":0.003100991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01790805555626811,"score_gpt":0.2884185843557259,"score_spread":0.2705105287994578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}