{"id":"W2060914655","doi":"10.1074/jbc.m405300200","title":"Disruption of a Salt Bridge Dramatically Accelerates Subunit Exchange in Duck δ2 Crystallin","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Protein subunit; Salt bridge; Bridge (graph theory); Salt (chemistry); Crystallin; Chemistry; Cell biology; Salt gland; Biophysics; Biology; Biochemistry; Anatomy; Organic chemistry; Secretion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004084772,0.0001070321,0.0002805434,0.00002975121,0.00002408954,0.00002525388,0.0001878429,0.0001753707,0.0007467347],"category_scores_gemma":[0.0002646743,0.00006980056,0.0000865882,0.0001283839,0.0001080446,0.0001135932,0.00003941381,0.0002140958,0.000006173427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006686729,"about_ca_system_score_gemma":0.00005116792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001373135,"about_ca_topic_score_gemma":0.000004308933,"domain_scores_codex":[0.9989612,0.00003484241,0.0005369233,0.0001227829,0.0001762111,0.0001680023],"domain_scores_gemma":[0.999293,0.00006470317,0.000344933,0.00009668491,0.0001239552,0.00007669714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403375,0.0001075821,0.0014029,0.00007358115,0.000004262005,0.00002603401,0.000103849,0.00008257798,0.9977499,0.00003440884,0.00003347639,0.000241116],"study_design_scores_gemma":[0.000692807,0.0002484739,0.03041941,0.0001044796,0.000009228231,0.00012975,0.00007912832,0.000005117466,0.964215,0.003874132,0.0001230739,0.00009936517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983933,0.0002379537,0.0005690908,0.000189718,0.000100994,0.00004261109,0.000008724041,0.000009468159,0.0004481168],"genre_scores_gemma":[0.9985627,0.0001035863,0.0009913752,0.00005655555,0.0002480979,0.000001439793,0.000005577788,0.000004437584,0.00002621297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03353484,"threshold_uncertainty_score":0.8176221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0337904466786232,"score_gpt":0.2704103224549737,"score_spread":0.2366198757763505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}