{"id":"W2060914851","doi":"10.1016/j.cbi.2012.11.017","title":"Acrolein and chloroacetaldehyde: An examination of the cell and cell-free biomarkers of toxicity","year":2012,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Chinese Academy of Agricultural Sciences","keywords":"Acrolein; Chemistry; Toxicity; Aldehyde dehydrogenase; Protein Carbonylation; Cytotoxicity; Biochemistry; Bovine serum albumin; Mesna; Hepatocyte; Viability assay; Lactate dehydrogenase; Glutathione; Pharmacology; Cell; Biology; Enzyme; Cisplatin; Ifosfamide; In vitro; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840182,0.0001030526,0.0001253028,0.00001902539,0.00005719449,0.000007054073,0.0001325176,0.0001181863,0.00003786834],"category_scores_gemma":[0.00005916128,0.00007172397,0.00005700698,0.00005491382,0.0002005834,0.000010383,0.0002410448,0.0000815075,2.769733e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001526675,"about_ca_system_score_gemma":0.000009857484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001184672,"about_ca_topic_score_gemma":0.000009191725,"domain_scores_codex":[0.9993771,0.0000589579,0.0001746963,0.0001771412,0.00005639383,0.0001557356],"domain_scores_gemma":[0.9994441,0.0000314381,0.0001242873,0.0002741093,0.00004909109,0.00007701465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003004544,0.0002435016,0.00770076,0.00002129849,0.00001953203,5.121653e-8,0.0001667999,0.00000100178,0.9908059,0.00002367647,0.0001081049,0.0008792936],"study_design_scores_gemma":[0.0002355644,0.0001501846,0.08871762,0.000004784408,0.00001415882,0.000009515266,0.0006179559,0.00002079484,0.9092573,0.000023886,0.0008694381,0.00007883349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978195,0.0003719224,0.00007908555,0.00004655391,0.00007942645,0.0001235484,0.00005855721,0.000004011376,0.001417328],"genre_scores_gemma":[0.9993304,0.0001348365,0.0002528582,0.00005785095,0.00005678122,0.00001532964,0.0000322619,0.000005501734,0.000114152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08154867,"threshold_uncertainty_score":0.2924818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039601783452596,"score_gpt":0.2688219189374428,"score_spread":0.2484259011029168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}