{"id":"W2060914851","doi":"10.1016/j.cbi.2012.11.017","title":"Acrolein and chloroacetaldehyde: An examination of the cell and cell-free biomarkers of toxicity","year":2012,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Chinese Academy of Agricultural Sciences","keywords":"Acrolein; Chemistry; Toxicity; Aldehyde dehydrogenase; Protein Carbonylation; Cytotoxicity; Biochemistry; Bovine serum albumin; Mesna; Hepatocyte; Viability assay; Lactate dehydrogenase; Glutathione; Pharmacology; Cell; Biology; Enzyme; Cisplatin; Ifosfamide; In vitro; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006902076,0.0004972121,0.0002689009,0.0008705544,0.0002962998,0.0004243833,0.0002848659,0.0006055393,0.0009488103],"category_scores_gemma":[0.0004821332,0.0002407383,0.0002056212,0.0006096285,0.000415895,0.0005978107,0.00039888,0.0005619113,0.00029609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805994,"about_ca_system_score_gemma":0.0004105872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002878,"about_ca_topic_score_gemma":0.001362788,"domain_scores_codex":[0.9995433,0.0001362178,0.00002762959,0.0000628628,0.0001857956,0.00004427847],"domain_scores_gemma":[0.9995273,0.0001279285,0.00007683259,0.00005673417,0.0001669939,0.00004406326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437574,0.00002680822,0.00118954,0.00004515313,0.00001385243,0.00005016256,0.00005279665,0.00007576206,0.996094,0.0001777696,0.00001948488,0.002110875],"study_design_scores_gemma":[0.000005219004,0.0005449289,0.008315179,0.000005859943,0.00002804432,0.0001975901,0.00008397908,0.00042465,0.9879749,0.000128794,0.002281938,0.000008970412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9520825,0.009548521,0.0309838,0.0001512991,0.00007326286,0.0001356228,0.0006318829,0.0001483441,0.006244832],"genre_scores_gemma":[0.9788632,0.002962114,0.01061485,0.0001094905,0.00002073185,0.0001126811,0.0007699413,0.00002270118,0.006524279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002878,"threshold_uncertainty_score":0.003650188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039601783452596,"score_gpt":0.2688219189374428,"score_spread":0.2484259011029168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}