{"id":"W2060928558","doi":"10.1016/j.ydbio.2009.08.022","title":"Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate","year":2009,"lang":"en","type":"article","venue":"Developmental Biology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Activin type 2 receptors; Biology; Follistatin; Trophoblast; Cell biology; Embryonic stem cell; Activin receptor; Nodal signaling; Cellular differentiation; NODAL; Cell culture; Fibroblast growth factor; ACVR2B; Stem cell; TGF beta signaling pathway; Internal medicine; Endocrinology; Transforming growth factor; Receptor; Placenta; Embryo; Embryogenesis; Anatomy; Genetics; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003440224,0.0003237357,0.0003331329,0.0005956596,0.0002244799,0.0006119107,0.0002439184,0.000288294,0.002224986],"category_scores_gemma":[0.0002052281,0.0002818688,0.0003528471,0.0002618349,0.0002343417,0.0002287417,0.0003970011,0.001046549,0.0007564501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004551165,"about_ca_system_score_gemma":0.0003944241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001757299,"about_ca_topic_score_gemma":0.003033429,"domain_scores_codex":[0.99979,0.00004288657,0.00002664036,0.00003576759,0.00005176306,0.00005289778],"domain_scores_gemma":[0.9996504,0.0001548439,0.00003742972,0.00004365757,0.00002292331,0.00009079525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001502896,0.00001515516,0.0002143541,0.00002231117,0.000005123198,0.00009336001,0.0000517752,0.00006055639,0.9984645,0.0001106974,0.00003045277,0.0007813897],"study_design_scores_gemma":[0.00001071609,0.00008349774,0.002028517,0.000006067361,0.00001028912,0.00007383584,0.00002779532,0.0003709921,0.9954726,0.0000331282,0.001880539,0.000001929464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844595,0.002263422,0.004093785,0.0001197904,0.00005420228,0.00004842331,0.000785822,0.0001372259,0.008037859],"genre_scores_gemma":[0.982928,0.001107212,0.002910302,0.00007305042,0.00002456722,0.00004310111,0.001034061,0.00008064027,0.01179906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002224986,"threshold_uncertainty_score":0.007443309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008641790200511177,"score_gpt":0.2222418586136643,"score_spread":0.2136000684131532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}