{"id":"W2061045375","doi":"10.1021/bi100304b","title":"Probing the Function of Nucleotides in the Catalytic Cores of the 8−17 and 10−23 DNAzymes by Abasic Nucleotide and C3 Spacer Substitutions","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Deoxyribozyme; Nucleotide; Nucleobase; AP site; DNA; RNA; Chemistry; Biochemistry; Biology; DNA repair; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002066847,0.0001132101,0.0001067648,0.00001391434,0.0001085137,0.00001686615,0.0001545135,0.0001074528,0.000001825275],"category_scores_gemma":[0.000121998,0.00005938569,0.00005721092,0.0001120504,0.0006826086,0.000004041206,0.00008771686,0.0001349596,1.294605e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000040553,"about_ca_system_score_gemma":0.0000305231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003958069,"about_ca_topic_score_gemma":0.00009836794,"domain_scores_codex":[0.9994023,0.00002580848,0.0001654282,0.0001993715,0.0000964457,0.0001106057],"domain_scores_gemma":[0.9993798,0.00003007248,0.0001312562,0.0003867015,0.00005257079,0.00001961128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000195734,0.00003115992,0.003516719,0.00002703311,0.00002133926,1.843695e-7,0.00003669529,6.08725e-7,0.9941227,0.00004273593,0.001661274,0.0005199199],"study_design_scores_gemma":[0.0001186003,0.00002981591,0.005124799,0.00002876673,0.00005033305,0.00001319435,0.0002999411,0.0000213517,0.9922706,0.00008464055,0.001877787,0.00008009809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984208,0.0005680568,0.00002720089,0.0004278474,0.0000218711,0.0001215126,0.00003113188,0.000006553363,0.0003750488],"genre_scores_gemma":[0.9992421,0.0001064146,0.0001449273,0.00007840807,0.00004325075,0.00000614259,0.00003236136,0.000006931928,0.000339476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852085,"threshold_uncertainty_score":0.25151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005624495629736138,"score_gpt":0.2273599372208857,"score_spread":0.2217354415911495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}