{"id":"W2061049371","doi":"10.1515/bc.2002.113","title":"Human Tissue Kallikreins: A New Enzymatic Cascade Pathway?","year":2002,"lang":"en","type":"review","venue":"Biological Chemistry","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Kallikrein; Proteases; Zymogen; Biology; Serine; Serine protease; Proteolytic enzymes; Biochemistry; Enzyme; Protease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001349618,0.000702356,0.002276856,0.00004372193,0.0001195212,0.00004014849,0.0003470732,0.001382283,0.005535127],"category_scores_gemma":[0.0002953038,0.0004737551,0.0007684049,0.0002564298,0.0001536646,0.00002835447,0.0001292994,0.0006203321,0.000460257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001627959,"about_ca_system_score_gemma":0.0002294118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003038044,"about_ca_topic_score_gemma":8.151338e-7,"domain_scores_codex":[0.9974104,0.00005484835,0.0009522099,0.0007763451,0.0002737926,0.0005323937],"domain_scores_gemma":[0.9982562,0.0001374211,0.0004007788,0.0006521126,0.00004886731,0.0005046214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006448063,0.0002638076,0.00003008949,0.01712988,0.000251852,0.0003075582,0.00004224027,6.92329e-8,0.0009052055,0.0001045581,0.01390019,0.9670581],"study_design_scores_gemma":[0.0004004961,0.0001270259,0.00003183218,0.006808924,0.0004650787,0.0004760474,0.000007687869,0.00000171419,0.0007814005,0.0001221726,0.9902408,0.0005367802],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002698562,0.9905535,0.000008693226,0.00006906277,0.0000922304,0.0006027855,0.00004296637,0.0002688623,0.008092036],"genre_scores_gemma":[0.0004686095,0.9604579,0.0002197268,0.0001520931,0.002106733,0.00007434813,0.0008361054,0.00006447805,0.03562003],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9763407,"threshold_uncertainty_score":0.9999141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1270546442766451,"score_gpt":0.3515569259715583,"score_spread":0.2245022816949132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}