{"id":"W2061050145","doi":"10.1021/bi801409r","title":"Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Efflux; P-glycoprotein; Cholesterol; ATP-binding cassette transporter; Chemistry; Lipid bilayer; Phospholipid; Biochemistry; Drug; ATPase; Multiple drug resistance; Transporter; Biology; Pharmacology; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005869422,0.0001760887,0.0002359203,0.00003321347,0.00009560768,0.000003571932,0.00007243125,0.00008704379,0.000008961112],"category_scores_gemma":[0.000009779005,0.0001093305,0.00008350691,0.0001139487,0.0001191474,0.00004466106,0.000009505192,0.0002445002,0.000002057608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004167444,"about_ca_system_score_gemma":0.00005772645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003783059,"about_ca_topic_score_gemma":0.00001187772,"domain_scores_codex":[0.9991591,0.00001297157,0.0001379266,0.0002610961,0.0002722215,0.0001566605],"domain_scores_gemma":[0.9994534,0.00003103557,0.0001017445,0.0002930718,0.00002995993,0.00009082051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006560467,0.0001898508,0.03252538,0.0008127285,0.0000481218,0.00006217918,0.0002907322,0.000001962149,0.9645219,0.00000162114,0.00003130933,0.000858185],"study_design_scores_gemma":[0.001691651,0.0000858452,0.07990286,0.000983334,0.0000699654,0.00009620999,0.00006230507,0.00001181594,0.9168952,0.000001265278,0.00009276351,0.0001067551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986178,0.00003125953,0.0000344757,0.0002926451,0.0001069293,0.0003739167,0.000008318269,0.0000374935,0.0004971498],"genre_scores_gemma":[0.997241,0.00002919816,0.0001104284,0.00005238372,0.00007920385,0.00002436765,0.00001319976,0.00002431912,0.002425891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04762666,"threshold_uncertainty_score":0.4458369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007720031857985062,"score_gpt":0.218926274522166,"score_spread":0.2112062426641809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}