{"id":"W2061050145","doi":"10.1021/bi801409r","title":"Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Efflux; P-glycoprotein; Cholesterol; ATP-binding cassette transporter; Chemistry; Lipid bilayer; Phospholipid; Biochemistry; Drug; ATPase; Multiple drug resistance; Transporter; Biology; Pharmacology; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003053655,0.0003853301,0.0005091116,0.0001927447,0.0002683232,0.0005739658,0.0003108997,0.000620653,0.0007818207],"category_scores_gemma":[0.0004876985,0.0001800445,0.0002318942,0.0002556817,0.0003842796,0.0005121856,0.0003381348,0.0004596013,0.0003032514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004415102,"about_ca_system_score_gemma":0.0002873885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000849703,"about_ca_topic_score_gemma":0.0006812726,"domain_scores_codex":[0.9997535,0.00007336224,0.00002285595,0.00003300404,0.00006481195,0.00005242788],"domain_scores_gemma":[0.9997742,0.00007999709,0.00004152539,0.00001973089,0.00003766375,0.00004693691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002167944,0.00003631816,0.0005463396,0.0002118697,0.0000167762,0.0001868026,0.00002701728,0.00005983086,0.9918628,0.0002865876,0.00008249102,0.006466298],"study_design_scores_gemma":[0.00002335484,0.0002579778,0.008636856,0.00001449842,0.00003109348,0.0005713269,0.00002711282,0.0004823655,0.9839529,0.0001423592,0.005845496,0.00001466429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9387435,0.05291066,0.003820088,0.0009819868,0.00008423624,0.00005773532,0.0001869758,0.00006892132,0.003145925],"genre_scores_gemma":[0.9803447,0.01471081,0.002413244,0.0001829133,0.00007283086,0.00003811676,0.0001733975,0.0000144009,0.002049657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000849703,"threshold_uncertainty_score":0.003203392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007720031857985062,"score_gpt":0.218926274522166,"score_spread":0.2112062426641809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}