{"id":"W2061052195","doi":"10.1093/hmg/ddu468","title":"Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Molecular biology; Mitochondrion; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002635825,0.0001720994,0.0001342619,0.0001621093,0.0001580191,0.00005123226,0.0002820109,0.0001864586,0.0001303811],"category_scores_gemma":[0.00008539783,0.0001604188,0.00005250469,0.0001707224,0.00006177075,0.000001733478,0.00006351559,0.0001219664,0.0001567138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003660784,"about_ca_system_score_gemma":0.00008958928,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001977717,"about_ca_topic_score_gemma":0.05642126,"domain_scores_codex":[0.9985682,0.0002906225,0.0002349571,0.00041268,0.0001469984,0.0003465599],"domain_scores_gemma":[0.9990793,0.00001548007,0.00004361524,0.000607365,0.00007450043,0.0001797434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003421199,0.00003426671,0.001471546,0.000007301631,0.00002220724,0.000137638,0.0002664521,0.001609619,0.9819666,0.001767954,0.00869278,0.003989397],"study_design_scores_gemma":[0.0006761182,0.0009710615,0.1136791,0.00001325564,0.00001773724,0.0002450499,0.00006294356,0.00005198695,0.066177,0.001021881,0.8166271,0.0004568318],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731128,0.000591545,0.02219438,0.0006062919,0.000460425,0.0003688182,0.00001162614,0.00001040435,0.002643706],"genre_scores_gemma":[0.9948779,0.00002726235,0.001423421,0.001869014,0.0001921362,0.00004627924,0.0001302554,0.00003440999,0.001399329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9157896,"threshold_uncertainty_score":0.9607966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0179229326063776,"score_gpt":0.2606786778342757,"score_spread":0.2427557452278981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}