{"id":"W2061068674","doi":"10.2174/1568026043387953","title":"Sulfonamide-Based Acyclic and Conformationally Constrained MMP Inhibitors: From Computer-Assisted Design to Nanomolar Compounds","year":2004,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Servier","keywords":"Enantiopure drug; Pyrrolidine; Aziridine; Sulfonamide; Chemistry; Hydroxamic acid; Combinatorial chemistry; Tetrahydrofuran; Peptidomimetic; Docking (animal); Stereochemistry; Enantioselective synthesis; Organic chemistry; Biochemistry; Medicine; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003287895,0.0008382333,0.0009054431,0.0009702186,0.0001686314,0.0007767969,0.000884651,0.0004368259,0.001913177],"category_scores_gemma":[0.0002175822,0.0003413024,0.0002465472,0.0009622222,0.0004338808,0.0007695789,0.0003646757,0.0008573005,0.002019991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006614449,"about_ca_system_score_gemma":0.0003778266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007754069,"about_ca_topic_score_gemma":0.001219729,"domain_scores_codex":[0.9999055,0.00001347719,0.000009630417,0.00001997538,0.00003876531,0.00001268156],"domain_scores_gemma":[0.9999503,0.0000146842,0.00000850813,0.000004114938,0.00001462585,0.000007735564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001696293,0.0002506502,0.0001512672,0.005425326,0.00005592624,0.0003265826,0.00010803,0.007925159,0.04664224,0.01285343,0.007089501,0.9190024],"study_design_scores_gemma":[0.0001686322,0.0006996972,0.0007226577,0.0007113621,0.00008326152,0.001602913,0.00006615594,0.004468483,0.047495,0.006241468,0.9376804,0.00005990803],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007929,0.9723181,0.01046495,0.0003987089,0.0001963421,0.00008220465,0.00006637908,0.0001738962,0.008370521],"genre_scores_gemma":[0.0246381,0.9581799,0.01080941,0.0002849438,0.0001263842,0.00009458125,0.000136905,0.00001759718,0.005712139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001913177,"threshold_uncertainty_score":0.006400287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06005045694330871,"score_gpt":0.321949288407082,"score_spread":0.2618988314637732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}