{"id":"W2061095282","doi":"10.1073/pnas.1009412107","title":"Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Hjärnfonden; Cancerfonden; Karolinska Institutet; Christopher and Dana Reeve Foundation","keywords":"Reprogramming; Biology; Ectopic expression; Embryonic stem cell; Neural stem cell; Stem cell; Somatic cell; Cell biology; Induced stem cells; Induced pluripotent stem cell; Cellular differentiation; Adult stem cell; Transcription factor; Neural development; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710192,0.0001461144,0.0001070515,0.0001295474,0.00008966249,0.0003158109,0.00007983371,0.00009743477,0.0007492687],"category_scores_gemma":[0.0001540674,0.00007271455,0.0001053066,0.0001380811,0.0001236103,0.00008323013,0.0002453582,0.0002901891,0.000473103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001179004,"about_ca_system_score_gemma":0.0002202453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433653,"about_ca_topic_score_gemma":0.0005569931,"domain_scores_codex":[0.9998565,0.00002385206,0.00001546243,0.00002216154,0.00004923481,0.00003281526],"domain_scores_gemma":[0.9999442,0.000007963399,0.0000118557,0.00001348447,0.000008277751,0.00001430458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000482513,0.00001473632,0.0003507236,0.00002136223,0.000003243743,0.00006544838,0.00003008004,0.0001244546,0.9904132,0.0004564994,0.00007300147,0.008398919],"study_design_scores_gemma":[0.00001320453,0.0001185401,0.002908005,0.00001031623,0.00001396659,0.0005159752,0.00003969427,0.001218719,0.9837029,0.0002565558,0.01119683,0.000005226127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9372024,0.001970384,0.05422254,0.0001617426,0.00007527694,0.0000743871,0.0004750178,0.0001997106,0.005618555],"genre_scores_gemma":[0.975962,0.001146849,0.01725632,0.0000585841,0.00001162827,0.00003814071,0.000471995,0.00002804996,0.005026375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007492687,"threshold_uncertainty_score":0.002506554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501270482753738,"score_gpt":0.2916812675474602,"score_spread":0.2666685627199228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}