{"id":"W2061097390","doi":"10.1007/s001980070028","title":"Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption","year":2000,"lang":"en","type":"review","venue":"Osteoporosis International","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":326,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"RANKL; Osteoclast; Osteoprotegerin; Bone resorption; Stromal cell; RANK Ligand; Cell biology; Receptor; Internal medicine; Osteoblast; Medicine; Chemistry; Cancer research; Endocrinology; Biology; Activator (genetics); In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001008888,0.001220918,0.002111726,0.001679304,0.0004663219,0.001548235,0.001543818,0.002253148,0.002616365],"category_scores_gemma":[0.0007286491,0.0003059177,0.0003874946,0.002466844,0.001331478,0.002479862,0.00084703,0.003428431,0.002839138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00122933,"about_ca_system_score_gemma":0.001806391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290237,"about_ca_topic_score_gemma":0.002421805,"domain_scores_codex":[0.9997372,0.00003100075,0.0000344524,0.00004219614,0.0001311326,0.00002406886],"domain_scores_gemma":[0.9996499,0.0001252247,0.00004023694,0.00001114337,0.0001049962,0.00006848531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002496423,0.00009579433,0.0002460914,0.006155417,0.00006320121,0.0005981587,0.00008299518,0.0003404956,0.006872967,0.008147552,0.08237757,0.8947701],"study_design_scores_gemma":[0.00004973112,0.00007331484,0.000432277,0.0005234574,0.00004786766,0.001407486,0.0000677325,0.00006569475,0.0005668161,0.002889317,0.9938608,0.00001539045],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001190047,0.9968793,0.0003852531,0.000820247,0.0009227067,0.000005640276,0.0000125016,0.00001229885,0.0008430892],"genre_scores_gemma":[0.0008786384,0.9950247,0.000664178,0.0009405119,0.0009845652,0.00001754118,0.00004383679,0.000002372909,0.001443549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002616365,"threshold_uncertainty_score":0.008919477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241087274136192,"score_gpt":0.2950767621467458,"score_spread":0.2709680347331266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}