{"id":"W2061113358","doi":"10.1093/nar/gkm543","title":"Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC","year":2007,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":265,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Small interfering RNA; Biology; RNA interference; Trans-acting siRNA; Gene silencing; microRNA; Argonaute; RNA-induced silencing complex; RNA; Computational biology; RNA silencing; Small hairpin RNA; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001315469,0.0001606944,0.0001925881,0.0001933029,0.0001606494,0.00004470883,0.0004771477,0.0002632974,0.0000328546],"category_scores_gemma":[0.0002731842,0.0001592626,0.00009033042,0.0003287585,0.0002734059,0.00001432617,0.0003397263,0.0003751466,0.00004610735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008189901,"about_ca_system_score_gemma":0.0001566753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002547867,"about_ca_topic_score_gemma":0.00008786499,"domain_scores_codex":[0.9982061,0.0001756934,0.0003632498,0.0004339587,0.0003884655,0.0004325066],"domain_scores_gemma":[0.998642,0.00007441934,0.0001075579,0.0003319457,0.000717202,0.0001268773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008978955,0.000186676,0.001340977,0.0000188757,0.00007301942,0.000004867992,0.0003514725,0.000007377789,0.9778331,0.000087685,0.006225395,0.01297268],"study_design_scores_gemma":[0.0007056714,0.00153548,0.001525048,0.00003957376,0.000007231349,0.000004415691,0.0004675456,0.00005953371,0.9904164,0.0004501789,0.004625333,0.0001635804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940163,0.0004213007,0.0009170498,0.00005807648,0.0002844381,0.0002427949,0.00000775353,0.0000137153,0.004038517],"genre_scores_gemma":[0.9986633,0.0001771004,0.0003215793,0.00002760797,0.0003528719,0.00001081771,0.00007791945,0.0000284907,0.0003403013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0128091,"threshold_uncertainty_score":0.6494541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296657666855188,"score_gpt":0.3255925137450575,"score_spread":0.2959267470595388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}