{"id":"W2061113358","doi":"10.1093/nar/gkm543","title":"Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC","year":2007,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":265,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Small interfering RNA; Biology; RNA interference; Trans-acting siRNA; Gene silencing; microRNA; Argonaute; RNA-induced silencing complex; RNA; Computational biology; RNA silencing; Small hairpin RNA; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005007574,0.0005681647,0.001013709,0.0004491846,0.0002435763,0.00112657,0.0005522562,0.0004257685,0.001239386],"category_scores_gemma":[0.000530167,0.0004736238,0.0003741163,0.0003258055,0.0005381233,0.000315341,0.0006137023,0.001078439,0.0008813341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007240084,"about_ca_system_score_gemma":0.000532663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004629991,"about_ca_topic_score_gemma":0.00113446,"domain_scores_codex":[0.9991539,0.0001020393,0.0001238129,0.0001556563,0.0003523194,0.0001124127],"domain_scores_gemma":[0.9993544,0.0002001899,0.0001644932,0.00009024935,0.00008538429,0.0001051921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003253945,0.0000297305,0.00007685927,0.00004157043,0.00001147496,0.00002786279,0.00000994767,0.0002342257,0.9980051,0.0002473523,0.0000569773,0.001226316],"study_design_scores_gemma":[0.000005574603,0.00008191858,0.0003091295,0.000002735663,0.00001947471,0.00005923405,0.000004749471,0.00175345,0.9964688,0.00002633403,0.001264473,0.000004097848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.953696,0.002376042,0.03673723,0.0001769757,0.0001037686,0.0002416382,0.0004428392,0.00100249,0.005223054],"genre_scores_gemma":[0.9708481,0.001136637,0.02230426,0.0001566268,0.00002970167,0.0002299737,0.0006646624,0.0002674806,0.004362533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239386,"threshold_uncertainty_score":0.005253017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296657666855188,"score_gpt":0.3255925137450575,"score_spread":0.2959267470595388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}