{"id":"W2061122794","doi":"10.1016/j.exphem.2013.12.001","title":"Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations","year":2013,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institutes of Health; Agios Pharmaceuticals; Johns Hopkins University; Leukemia and Lymphoma Society","keywords":"Myeloid leukemia; Glutaminase; Cancer research; Primary (astronomy); Myeloid; Myeloid cells; Leukemia; Chemistry; Biology; Immunology; Genetics; Glutamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711712,0.0004884725,0.0005814357,0.0003504521,0.0001800273,0.0004715399,0.0003674284,0.0002663498,0.001339423],"category_scores_gemma":[0.0001427232,0.000168957,0.000287696,0.0003031499,0.0003569334,0.0001478798,0.0002143861,0.0008871234,0.0004542631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004497347,"about_ca_system_score_gemma":0.0003752176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008306215,"about_ca_topic_score_gemma":0.001387983,"domain_scores_codex":[0.9997771,0.00003662741,0.0000248507,0.00002990089,0.00005977819,0.00007163765],"domain_scores_gemma":[0.9998114,0.00004725657,0.00003729873,0.00003104966,0.0000112591,0.00006184102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00041019,0.0001169188,0.0002414972,0.00002014367,0.000007278145,0.00006740701,0.0000152996,0.0001102718,0.997724,0.0001640737,0.00009484949,0.001027966],"study_design_scores_gemma":[0.00004740574,0.0004386939,0.001636246,0.000002316325,0.00001147657,0.0001784259,0.00002379071,0.0005141781,0.9959893,0.00002604362,0.001130076,0.000002173727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963408,0.0008244722,0.0009665272,0.0001062814,0.00004999147,0.00003120139,0.0004366928,0.0001185443,0.001125548],"genre_scores_gemma":[0.996379,0.0004105215,0.0009251046,0.00003137745,0.00001059365,0.00002940272,0.0005235294,0.00002500393,0.001665656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339423,"threshold_uncertainty_score":0.004480839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106727708581059,"score_gpt":0.2677154683352946,"score_spread":0.2570426974771887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}