{"id":"W2061123524","doi":"10.1523/jneurosci.2775-12.2012","title":"The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus","year":2012,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Wellcome Trust","keywords":"Presenilin; Amyloid precursor protein; Genetically modified mouse; Extracellular; Hippocampal formation; Hippocampus; Intracellular; Transgene; Amyloid precursor protein secretase; Cell biology; Chemistry; Neuroscience; Colocalization; Amyloid (mycology); Mutant; Internal medicine; Endocrinology; Biology; Biochemistry; Alzheimer's disease; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009276788,0.0004567378,0.0002609272,0.0006246554,0.0001877194,0.0004425523,0.0002260289,0.0005097234,0.0008501018],"category_scores_gemma":[0.00009984544,0.0002573863,0.0003086022,0.0002214664,0.0003094822,0.0004156974,0.0002827044,0.0008837984,0.0003868042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002397243,"about_ca_system_score_gemma":0.0001889417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008330923,"about_ca_topic_score_gemma":0.001095705,"domain_scores_codex":[0.9998728,0.000005234947,0.00002027581,0.0000393083,0.00003650738,0.0000259066],"domain_scores_gemma":[0.9997444,0.00001372505,0.000105825,0.00001666844,0.00002510629,0.00009432145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000501575,0.000008960384,0.0001775413,0.00001159772,0.000002609193,0.00009916411,0.00001097836,0.000004258522,0.9993712,0.00001708348,0.000007378396,0.0002391402],"study_design_scores_gemma":[0.00001891301,0.0003678612,0.03715131,0.00001813176,0.00003868619,0.002524135,0.00009981538,0.0002422244,0.9581794,0.0001225521,0.001226999,0.000009812063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996268,0.001078124,0.001269268,0.00006312651,0.00002141684,0.00001675015,0.0004106676,0.00006554841,0.0008072906],"genre_scores_gemma":[0.9913571,0.001970679,0.002117594,0.00009941602,0.00001753143,0.00004824286,0.0008694452,0.00004192828,0.003478029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008501018,"threshold_uncertainty_score":0.002843916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04090532317857678,"score_gpt":0.3247111801682484,"score_spread":0.2838058569896716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}