{"id":"W2061130471","doi":"10.1021/np401019t","title":"Discovery, Isolation, and Structure Elucidation of Dretamycin","year":2014,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Candida albicans; Mutant; Heterozygote advantage; Compound heterozygosity; Biology; Streptomyces; Phenotypic screening; Isolation (microbiology); Phenotype; Genetics; Gene; Microbiology; Allele; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003689322,0.0001139763,0.0003418017,0.0001431346,0.00003674424,0.00002472219,0.00007300214,0.00007094493,0.00001318359],"category_scores_gemma":[0.001526926,0.0000681707,0.00005836646,0.000216745,0.00006704112,0.0004106726,0.00002472697,0.0003160472,6.391015e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002316555,"about_ca_system_score_gemma":0.00005753849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004673037,"about_ca_topic_score_gemma":0.000001803989,"domain_scores_codex":[0.999014,0.00005226903,0.000420548,0.0001566001,0.0002470612,0.0001095115],"domain_scores_gemma":[0.9985914,0.00004545271,0.0004875887,0.0001623503,0.0006695566,0.00004365299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003132681,0.00002855456,0.001006902,0.000169657,0.00005145036,0.000002069015,0.00008388991,0.000001812506,0.9818444,0.0001669964,0.003346487,0.01298454],"study_design_scores_gemma":[0.0008192339,0.000425672,0.05580628,0.0001903855,0.0001639115,0.0005300735,0.00002384536,0.00007698771,0.9360062,0.0003894733,0.005459831,0.0001081174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869982,0.002070529,0.00003824232,0.01016491,0.0005264771,0.000143226,0.000004151696,0.000005013144,0.00004927164],"genre_scores_gemma":[0.9950616,0.0001039122,0.003152002,0.0001879418,0.001002174,2.038785e-8,0.000006931275,0.000009293954,0.0004760866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05479938,"threshold_uncertainty_score":0.2779921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005892046867466415,"score_gpt":0.2246346616004748,"score_spread":0.2187426147330084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}