{"id":"W2061132293","doi":"10.1124/mol.62.3.608","title":"Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38)","year":2002,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":341,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund","keywords":"Glucuronidation; Metabolite; SN-38; Microsome; Glucuronosyltransferase; Irinotecan; UGT2B7; Glucuronide; Toxicity; Active metabolite; Chemistry; Isozyme; Metabolism; Enzyme; In vitro; Biochemistry; Pharmacology; Biology; Genetics; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002930768,0.0003072141,0.0005054716,0.00009417726,0.0001536292,0.00002006247,0.0003959985,0.0001968777,0.0005634742],"category_scores_gemma":[0.00001128755,0.0002495134,0.0002278213,0.0001382096,0.000512952,0.000006056808,0.0002548186,0.0002204402,0.000008574529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001537561,"about_ca_system_score_gemma":0.00002481325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001051434,"about_ca_topic_score_gemma":0.00001642537,"domain_scores_codex":[0.9981298,0.0004159523,0.0003744927,0.0004763476,0.0001861201,0.000417228],"domain_scores_gemma":[0.9990433,0.00003002964,0.000244751,0.0004643427,0.00008892681,0.0001286067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003619083,0.0001415137,0.000005525696,0.00001178455,0.0005359444,0.000008716265,0.0002524893,0.00003553363,0.9888719,0.00342183,0.0005788935,0.005773977],"study_design_scores_gemma":[0.004788307,0.0002559303,0.00009739654,0.000003832004,0.0003407763,0.00003356398,0.00003285169,0.0002707525,0.9180908,0.001109468,0.07472509,0.00025129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781931,0.01548684,0.001155806,0.001151247,0.0005076774,0.0006568225,0.00008470215,0.00002082621,0.002742959],"genre_scores_gemma":[0.9945633,0.00133012,0.0001286342,0.002567043,0.0002839948,0.0001040461,0.00004265706,0.00005491464,0.0009252809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0741462,"threshold_uncertainty_score":0.9999957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304431530848102,"score_gpt":0.2737408960482914,"score_spread":0.2606965807398104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}