{"id":"W2061132293","doi":"10.1124/mol.62.3.608","title":"Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38)","year":2002,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":341,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund","keywords":"Glucuronidation; Metabolite; SN-38; Microsome; Glucuronosyltransferase; Irinotecan; UGT2B7; Glucuronide; Toxicity; Active metabolite; Chemistry; Isozyme; Metabolism; Enzyme; In vitro; Biochemistry; Pharmacology; Biology; Genetics; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002538713,0.0008282022,0.0006341599,0.0009158908,0.0004477802,0.0003969372,0.0003098796,0.001075101,0.003106191],"category_scores_gemma":[0.0008993316,0.0003865348,0.0004710708,0.0009594996,0.0004249843,0.000251785,0.0002308043,0.0006352848,0.0003119352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003830768,"about_ca_system_score_gemma":0.0002509795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002941045,"about_ca_topic_score_gemma":0.002149308,"domain_scores_codex":[0.9995796,0.0001121584,0.00005189752,0.000140964,0.00006980425,0.00004549038],"domain_scores_gemma":[0.9990989,0.0002520636,0.0003882396,0.00006762845,0.00004474173,0.0001483756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01905529,0.0007089272,0.7255004,0.0001710632,0.00153593,0.02045116,0.0005893077,0.001978609,0.2103305,0.001400026,0.0007315381,0.0175472],"study_design_scores_gemma":[0.0002988969,0.001762046,0.9424021,0.00002309319,0.0008600801,0.02842063,0.000156461,0.002383268,0.02124803,0.0007113707,0.001692688,0.00004125318],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998206,0.0004522229,0.0002619559,0.00009486872,0.00001323507,0.000008745714,0.0002973557,0.00002145562,0.0006442135],"genre_scores_gemma":[0.9992421,0.00009218018,0.0001626974,0.00002383144,0.00001319446,0.000004044653,0.0001461601,0.000005953624,0.0003097735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003106191,"threshold_uncertainty_score":0.01039118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304431530848102,"score_gpt":0.2737408960482914,"score_spread":0.2606965807398104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}