{"id":"W2061173299","doi":"10.1073/pnas.98.4.1619","title":"A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Mdm2; Ubiquitin; Transfection; Biology; Regulator; Cell biology; Cancer research; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009956908,0.0001399805,0.0002558719,0.0002385199,0.0001806337,0.0000257068,0.0003081789,0.0001499351,0.0000213983],"category_scores_gemma":[0.0006099291,0.000100066,0.00009241412,0.0007900082,0.00093059,0.0003828188,0.00007322861,0.000232934,0.00000305025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008403351,"about_ca_system_score_gemma":0.0000800132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001134057,"about_ca_topic_score_gemma":2.037472e-7,"domain_scores_codex":[0.9977826,0.000007810998,0.0003892625,0.0003330364,0.001280279,0.0002069538],"domain_scores_gemma":[0.9989701,0.00008292931,0.0004187736,0.00001707959,0.0004284546,0.0000826874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001670476,0.00009126814,0.0219108,0.000123253,0.00007554538,9.282604e-8,0.0001851395,0.0002061924,0.9582459,0.01471531,0.00158546,0.002694],"study_design_scores_gemma":[0.003562981,0.0003449634,0.5070981,0.0007526284,0.0002184617,0.0003317227,0.0003781011,0.0183536,0.4384977,0.02851468,0.001614682,0.0003323281],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878781,0.00100237,0.000009185717,0.007150675,0.00003176782,0.0004053602,0.00001063588,0.00002653036,0.003485397],"genre_scores_gemma":[0.9978319,0.0001599558,0.0007720235,0.0006080861,0.0001007439,0.00001266113,6.232762e-7,0.000009437836,0.0005045658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5197482,"threshold_uncertainty_score":0.4080572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02752351731074789,"score_gpt":0.2795597585479668,"score_spread":0.252036241237219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}