{"id":"W2061188620","doi":"10.1016/j.bmcl.2010.09.084","title":"Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Achaogen","keywords":"Aminoglycoside; Chemistry; Antibiotics; Amphiphile; Bacteria; Stereochemistry; Biophysics; Combinatorial chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058403,0.0002377654,0.0003547399,0.0001217275,0.000296789,0.0006069584,0.0003985294,0.0003392644,0.0008856432],"category_scores_gemma":[0.0003593186,0.0003204027,0.0001946093,0.0001357381,0.0001802224,0.0002470013,0.0001991979,0.0007117999,0.0004107802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000657686,"about_ca_system_score_gemma":0.0004391091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000700318,"about_ca_topic_score_gemma":0.001401615,"domain_scores_codex":[0.9998724,0.00002526169,0.00001486719,0.00002146383,0.00004386285,0.00002203946],"domain_scores_gemma":[0.9999028,0.00002571178,0.00002100704,0.00001200535,0.0000167557,0.00002164608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001410855,0.000125133,0.0001691274,0.0000730367,0.00001007178,0.00004122345,0.00003309493,0.003517516,0.9907817,0.0007116029,0.000221578,0.004174761],"study_design_scores_gemma":[0.00005626827,0.00011206,0.0001798819,0.000003380771,0.000009595533,0.00004766258,0.00001649149,0.007964705,0.9895915,0.00004326743,0.001969254,0.000005966975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885553,0.0008223386,0.008263458,0.0002132788,0.00003300834,0.00009340102,0.0001604984,0.0001467335,0.001712035],"genre_scores_gemma":[0.9774918,0.0007597159,0.01935658,0.00005901354,0.00001143573,0.00009352907,0.0003085084,0.00006074178,0.001858727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008856432,"threshold_uncertainty_score":0.004771888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009154533246312145,"score_gpt":0.2159594945902812,"score_spread":0.2068049613439691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}