{"id":"W2061188756","doi":"10.1172/jci40433","title":"An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":true,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Lawson Health Research Institute","keywords":"Metastasis; Cancer research; Cancer; Biology; Biomarker; Melanoma; Downregulation and upregulation; Gene knockdown; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":{"nature":"Retraction","reason":"Investigation by Company/Institution;Unreliable Data;","date":"3/18/2019 0:00","openalex_flagged":true},"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189353,0.0002401792,0.0002169613,0.0003576898,0.0001274387,0.0003168988,0.00009385914,0.0002662133,0.0006524517],"category_scores_gemma":[0.0005178304,0.0000955248,0.0001176121,0.0002644528,0.0003252445,0.000176819,0.0001542502,0.0004377332,0.0002058083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000220256,"about_ca_system_score_gemma":0.0001613334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003887504,"about_ca_topic_score_gemma":0.0004172046,"domain_scores_codex":[0.9998292,0.00003523218,0.00001649366,0.00004168297,0.00006242216,0.00001500097],"domain_scores_gemma":[0.9996653,0.00006646325,0.0001280543,0.00002816226,0.00005321392,0.00005879542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001398909,0.0001425688,0.1122326,0.0001873892,0.0000638062,0.001110718,0.0000454021,0.0002796268,0.86007,0.0002245336,0.0004923825,0.02375214],"study_design_scores_gemma":[0.00006533481,0.001307386,0.5066206,0.00003591679,0.0001122064,0.0093892,0.0001822531,0.003748912,0.4716116,0.00054127,0.006354812,0.00003043458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98766,0.006094116,0.003952396,0.0002273591,0.00005680086,0.00003699611,0.0004363602,0.00006871804,0.001467285],"genre_scores_gemma":[0.9941548,0.001857785,0.002246882,0.00009432307,0.00002553317,0.00001763507,0.0005323582,0.000006990166,0.001063715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006524517,"threshold_uncertainty_score":0.002182722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07579314404921753,"score_gpt":0.3616556316969689,"score_spread":0.2858624876477514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}