{"id":"W2061201213","doi":"10.1016/j.clinbiochem.2014.07.032","title":"Is confirmatory genetic testing of all CF screen positives justified?","year":2014,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Thiopurine methyltransferase; Genotyping; TaqMan; Single-nucleotide polymorphism; Biology; Genotype; genomic DNA; ITPA; Amplicon; Molecular biology; Genetics; Azathioprine; Medicine; Polymerase chain reaction; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005870395,0.0007858494,0.00132479,0.001514329,0.001127291,0.002230631,0.00173082,0.007671248,0.006118723],"category_scores_gemma":[0.05930083,0.0004537941,0.0009912295,0.000952223,0.002378376,0.00308518,0.0006191782,0.004748826,0.002107078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001271231,"about_ca_system_score_gemma":0.002897967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004577813,"about_ca_topic_score_gemma":0.005253992,"domain_scores_codex":[0.9954053,0.001862104,0.0006164302,0.000473698,0.001039329,0.0006030782],"domain_scores_gemma":[0.9625243,0.02500414,0.002163855,0.001833825,0.005479205,0.002994762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.005677269,0.0007924289,0.4553539,0.001080539,0.0005371991,0.04161305,0.0008751944,0.002075244,0.01055084,0.02251051,0.1467159,0.312218],"study_design_scores_gemma":[0.001580534,0.00402734,0.3300634,0.01823653,0.002540823,0.1449636,0.009275776,0.01598346,0.0189188,0.1245278,0.329273,0.0006089944],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2419899,0.04708896,0.01556197,0.6165319,0.01635472,0.0002193348,0.001134784,0.0004744348,0.06064405],"genre_scores_gemma":[0.8491011,0.01416914,0.02026079,0.09506746,0.01630014,0.0001386981,0.0008574537,0.0001347301,0.003970372],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.007671248,"threshold_uncertainty_score":0.03104603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07598253854597248,"score_gpt":0.3907073117332401,"score_spread":0.3147247731872677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}