{"id":"W2061209675","doi":"10.2217/14622416.8.10.1385","title":"Genetic Variability in<i>CYP2A6</i>and the Pharmacokinetics of Nicotine","year":2007,"lang":"en","type":"review","venue":"Pharmacogenomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; Centre for Addiction and Mental Health","keywords":"CYP2A6; Nicotine; Pharmacokinetics; Pharmacology; Biology; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004554807,0.0006453844,0.001116646,0.001176821,0.000183145,0.0005903317,0.0006026616,0.0009161055,0.003828848],"category_scores_gemma":[0.0004996294,0.0002175843,0.0003901071,0.001552555,0.0002660177,0.000801191,0.0003188806,0.0008408814,0.004049583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000414386,"about_ca_system_score_gemma":0.0006056083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001289463,"about_ca_topic_score_gemma":0.001633722,"domain_scores_codex":[0.9998291,0.00003076682,0.00001959231,0.00003798876,0.00006956027,0.00001299595],"domain_scores_gemma":[0.9998116,0.00008288363,0.00002938092,0.000006032722,0.00005299143,0.00001698605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006162735,0.00005774025,0.0004686052,0.00356635,0.00006116817,0.0002074699,0.00002175165,0.000222134,0.001595657,0.001241261,0.01382247,0.9786736],"study_design_scores_gemma":[0.00002329986,0.000127563,0.004645983,0.001333654,0.0001059524,0.003666808,0.00004461109,0.0001379261,0.001237666,0.001583486,0.987071,0.00002207226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003742919,0.9964566,0.0003470751,0.0003480267,0.0001364519,0.000007035819,0.00003137074,0.00001325214,0.002285948],"genre_scores_gemma":[0.001151123,0.9964755,0.0003463957,0.0001378885,0.000166448,0.000007511127,0.00005239011,0.000001919729,0.001660843],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003828848,"threshold_uncertainty_score":0.0128088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.182097976316047,"score_gpt":0.4837606931305429,"score_spread":0.3016627168144959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}