{"id":"W2061222476","doi":"10.1158/0008-5472.can-08-0265","title":"Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; Deutsche Forschungsgemeinschaft","keywords":"Pregnane X receptor; Organic anion-transporting polypeptide; Nuclear receptor; Estrogen receptor; Transporter; Biology; Chromatin immunoprecipitation; Breast cancer; Solute carrier family; Multidrug resistance-associated protein 2; Organic anion transporter 1; Cancer research; Pharmacology; Transcription factor; Gene expression; Cancer; ATP-binding cassette transporter; Promoter; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001136646,0.0003500914,0.0006742417,0.0002033125,0.0004890303,0.00003938923,0.0004381039,0.000216212,0.001496777],"category_scores_gemma":[0.00001888602,0.0001950213,0.0001747977,0.0009516631,0.001085463,0.0001829323,0.00002693412,0.001266778,0.00003727953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003144001,"about_ca_system_score_gemma":0.0005080827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287862,"about_ca_topic_score_gemma":0.001259895,"domain_scores_codex":[0.9966698,0.0002984326,0.0005224565,0.0006891272,0.0009193043,0.0009009076],"domain_scores_gemma":[0.9987345,0.000235342,0.00009387891,0.0004327119,0.0002422167,0.0002613027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01530694,0.0004752844,0.2604403,0.001367306,0.001163042,0.0002761756,0.03780764,0.000005925402,0.6393265,0.00068703,0.00517166,0.03797226],"study_design_scores_gemma":[0.01116212,0.0005773826,0.8477939,0.003269376,0.0003383254,0.0001094707,0.001514609,0.00002579443,0.1130347,0.0001914996,0.02132882,0.0006540086],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984408,0.00453549,0.0000710705,0.008434976,0.0002331868,0.001906873,0.0001401113,0.00006444116,0.0002058404],"genre_scores_gemma":[0.9887453,0.008239615,0.00009500953,0.0003120738,0.0005753835,0.0004951246,0.00003493356,0.0001014865,0.001401065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5873537,"threshold_uncertainty_score":0.999416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210427082642996,"score_gpt":0.3178692647205235,"score_spread":0.2968265564562239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}