{"id":"W2061222476","doi":"10.1158/0008-5472.can-08-0265","title":"Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; Deutsche Forschungsgemeinschaft","keywords":"Pregnane X receptor; Organic anion-transporting polypeptide; Nuclear receptor; Estrogen receptor; Transporter; Biology; Chromatin immunoprecipitation; Breast cancer; Solute carrier family; Multidrug resistance-associated protein 2; Organic anion transporter 1; Cancer research; Pharmacology; Transcription factor; Gene expression; Cancer; ATP-binding cassette transporter; Promoter; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640582,0.000206042,0.0003993903,0.0001621603,0.0001301031,0.0003154604,0.0001186543,0.0001614031,0.001272137],"category_scores_gemma":[0.000154321,0.0001472804,0.0002302036,0.0001411017,0.0001848288,0.0001434179,0.0001648759,0.0003200938,0.0002870259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344687,"about_ca_system_score_gemma":0.0002556622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004540561,"about_ca_topic_score_gemma":0.0009369606,"domain_scores_codex":[0.9998195,0.00004672546,0.00001154035,0.00002721301,0.00004820257,0.00004695103],"domain_scores_gemma":[0.9999254,0.00002359219,0.00001354036,0.000007960198,0.000008729844,0.00002075752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001439664,0.00003157459,0.0003217351,0.00003321002,0.000006047694,0.0000573004,0.00001324475,0.0000375209,0.9980749,0.00004196354,0.00003551557,0.001203003],"study_design_scores_gemma":[0.00005169608,0.001613376,0.01906236,0.000007571686,0.00005351455,0.0007277178,0.000121558,0.0009882144,0.9710431,0.00007394613,0.006247959,0.000008999896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937648,0.003917903,0.0008113241,0.0001737789,0.00003018833,0.00001604237,0.0001087925,0.00005360866,0.001123496],"genre_scores_gemma":[0.9950972,0.001751934,0.0006527863,0.00007012107,0.00001648194,0.00002561667,0.0002583873,0.0000115866,0.002115869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272137,"threshold_uncertainty_score":0.004255712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210427082642996,"score_gpt":0.3178692647205235,"score_spread":0.2968265564562239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}