{"id":"W2061252595","doi":"10.1038/sj.onc.1203396","title":"The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells","year":2000,"lang":"en","type":"article","venue":"Oncogene","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; BC Children's Hospital","funders":"National Cancer Institute; Medical Research Council Canada","keywords":"Biology; Fusion protein; Fusion gene; Chimeric gene; ETV6; Gene; Tyrosine kinase; Oncogene Proteins; Tyrosine; Molecular biology; Receptor tyrosine kinase; Genetics; Cell biology; Kinase; Signal transduction; Gene expression; Regulation of gene expression; Biochemistry; Chromosomal translocation; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785428,0.0005956951,0.0003639832,0.0004883075,0.0003744067,0.0004629545,0.0005389485,0.0007609381,0.002325429],"category_scores_gemma":[0.0001783982,0.0002906856,0.0003920943,0.00049016,0.0003865435,0.0004378561,0.0003061187,0.001184073,0.001665898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077625,"about_ca_system_score_gemma":0.0003560457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002829057,"about_ca_topic_score_gemma":0.003293897,"domain_scores_codex":[0.9998088,0.00001802903,0.00002083867,0.00003821641,0.0000680548,0.00004597328],"domain_scores_gemma":[0.9998181,0.00004736825,0.00004373879,0.0000258782,0.00001957531,0.00004536345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001456844,0.00002806175,0.0001149927,0.00002003753,0.000006373401,0.00008524931,0.00001625099,0.000129761,0.9973027,0.000714164,0.0001809433,0.001255811],"study_design_scores_gemma":[0.00005305297,0.00008021033,0.001856093,0.000004197674,0.00001795741,0.0005548909,0.00002112669,0.001906652,0.9837001,0.0001813483,0.01161393,0.0000105677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565475,0.001224625,0.02358896,0.0006214191,0.0002120307,0.0001504025,0.0072302,0.0007730349,0.00965195],"genre_scores_gemma":[0.9455624,0.0008038835,0.01826487,0.0001275108,0.00003359899,0.0001245512,0.01163628,0.0002621264,0.02318482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002829057,"threshold_uncertainty_score":0.007818758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00613655177988854,"score_gpt":0.2119963950918828,"score_spread":0.2058598433119943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}