{"id":"W2061278069","doi":"10.1158/1538-7445.am2011-290","title":"Abstract 290: Use of serum and tissue biomarker analysis embedded in a phase II clinical trial of cytarabine in castration-refractory prostate cancer to investigate prostate cancer biology","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Health Sciences Centre; University Health Network","funders":"","keywords":"TMPRSS2; Prostate cancer; Docetaxel; Medicine; PCA3; Oncology; Internal medicine; Cytarabine; Prostate; Cancer; Mitoxantrone; Cancer research; Urology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001902398,0.0007109962,0.0007196183,0.000247388,0.0002541743,0.000634043,0.0003877902,0.0006527898,0.00132631],"category_scores_gemma":[0.001255037,0.0002389984,0.0002928796,0.0002403909,0.0004558614,0.0003532156,0.0001895184,0.001633134,0.000305734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000511548,"about_ca_system_score_gemma":0.0008855589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003336415,"about_ca_topic_score_gemma":0.0006359188,"domain_scores_codex":[0.9994451,0.0003104321,0.00003317386,0.00008336129,0.00007205318,0.00005588474],"domain_scores_gemma":[0.9991845,0.0001999994,0.0001592237,0.00008418021,0.00009353726,0.000278481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3386524,0.06219342,0.04964203,0.0006364633,0.0007704917,0.000618048,0.0003073242,0.003531545,0.396457,0.0004064111,0.003467046,0.1433179],"study_design_scores_gemma":[0.1227548,0.7538223,0.06140097,0.00002833673,0.0003472059,0.0006781942,0.00003940954,0.00402721,0.05340731,0.0001661143,0.003296247,0.0000318452],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956713,0.0006339659,0.0008242883,0.0001432747,0.00004549234,0.001362869,0.0004336322,0.00004816257,0.0008370957],"genre_scores_gemma":[0.9945061,0.0002153104,0.001874971,0.0002328702,0.00004925894,0.001305186,0.001178535,0.00001246657,0.0006253255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001902398,"threshold_uncertainty_score":0.01006097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3606366684749604,"score_gpt":0.5433848099392202,"score_spread":0.1827481414642598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}