{"id":"W2061298261","doi":"10.1038/onc.2009.443","title":"Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Biology; Helicase; Exonuclease; Cell biology; Molecular biology; Kinase; Nuclear protein; Protein kinase A; DNA repair; DNA replication; Premature aging; Genome instability; DNA damage; Phosphorylation; Protein kinase C; Transcription factor; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003230359,0.0008758975,0.0003412985,0.0006782845,0.0004995562,0.0005621291,0.0005788832,0.0004501407,0.003010963],"category_scores_gemma":[0.0002298832,0.0004289549,0.0008625958,0.0003653,0.0004564658,0.0004616796,0.0003286754,0.001650554,0.0006663729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001392845,"about_ca_system_score_gemma":0.0005596498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002568635,"about_ca_topic_score_gemma":0.004412275,"domain_scores_codex":[0.9996302,0.0000343693,0.00004762943,0.00009387127,0.00007231982,0.0001215308],"domain_scores_gemma":[0.9996295,0.00004566156,0.00009181166,0.00007990364,0.00003776569,0.0001153916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001910203,0.00003758992,0.00007365451,0.0000315476,0.000006818724,0.00004268052,0.00001072533,0.00004518136,0.9989016,0.0001927645,0.00006183951,0.0004045701],"study_design_scores_gemma":[0.00001552738,0.00004506674,0.001491445,0.000003370879,0.00000892624,0.00008861444,0.00001838498,0.0004827033,0.9964018,0.00004134243,0.001398967,0.000003820315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864023,0.002500889,0.005112933,0.0004275099,0.0002045103,0.00009725144,0.00150651,0.0002959648,0.003452166],"genre_scores_gemma":[0.9814736,0.001274015,0.004350633,0.0001184113,0.00002107648,0.0001580537,0.001937789,0.00008375284,0.01058256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003010963,"threshold_uncertainty_score":0.01010585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00888895339218623,"score_gpt":0.24874035440505,"score_spread":0.2398514010128638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}