{"id":"W2061298261","doi":"10.1038/onc.2009.443","title":"Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Biology; Helicase; Exonuclease; Cell biology; Molecular biology; Kinase; Nuclear protein; Protein kinase A; DNA repair; DNA replication; Premature aging; Genome instability; DNA damage; Phosphorylation; Protein kinase C; Transcription factor; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537428,0.0001668419,0.0001681919,0.00005104041,0.00004536655,0.00001235505,0.0001714412,0.0001434862,0.00003696783],"category_scores_gemma":[0.00008343729,0.0001523443,0.00008969365,0.0001188255,0.00001985723,0.00000657266,0.00007194561,0.00006020992,0.00002551007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002944055,"about_ca_system_score_gemma":0.00007560959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002792592,"about_ca_topic_score_gemma":0.00002501309,"domain_scores_codex":[0.9989688,0.00004221988,0.0002150413,0.0003299062,0.0001761372,0.0002678912],"domain_scores_gemma":[0.9992869,0.000001769944,0.0001010605,0.0004044431,0.00009260802,0.0001132287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002378404,0.0001225123,0.0000330371,0.00001593038,0.00001989899,0.000006655853,0.00002724308,0.00003803358,0.9887217,0.0001027655,0.0001525799,0.01052174],"study_design_scores_gemma":[0.0004509877,0.001275743,0.0003765508,0.00003956876,0.000007101629,0.000008489483,0.00001673201,0.0000141278,0.9906377,0.0002851539,0.006691073,0.0001967988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946383,0.00006332973,0.003434312,0.0002732161,0.00004267777,0.0008414334,0.00001954133,0.00002911902,0.000658081],"genre_scores_gemma":[0.9883394,0.00000589196,0.009066419,0.000298578,0.00013995,0.00008230741,0.00005480346,0.00002291113,0.001989686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01032495,"threshold_uncertainty_score":0.6212422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00888895339218623,"score_gpt":0.24874035440505,"score_spread":0.2398514010128638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}