{"id":"W2061301855","doi":"10.1074/jbc.m110.107201","title":"Calnexin Deficiency Leads to Dysmyelination","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Calgary; University of Alberta","funders":"National Institute on Aging; National Science Foundation; Canadian Institutes of Health Research; U.S. Public Health Service; Multiple Sclerosis Society; Retina Research Foundation; Multiple Sclerosis Society of Canada; Alberta Innovates; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Heart and Stroke Foundation of Canada; March of Dimes Foundation","keywords":"Calnexin; Myelin; Biology; Cell biology; Central nervous system; Calreticulin; Endoplasmic reticulum; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075496,0.0006973283,0.0002281222,0.0006137184,0.000184422,0.0002658698,0.0002493195,0.0005540142,0.00183492],"category_scores_gemma":[0.0001970835,0.0001980431,0.0002636535,0.0002221478,0.0003252287,0.0001771352,0.0003796963,0.0006148372,0.0003557315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002692721,"about_ca_system_score_gemma":0.000152652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007360998,"about_ca_topic_score_gemma":0.000815296,"domain_scores_codex":[0.9997657,0.00003160459,0.00003262652,0.00007074141,0.00006360534,0.00003565991],"domain_scores_gemma":[0.9996778,0.00004795179,0.0001271708,0.00002549497,0.00002151539,0.0001000591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008787722,0.00002489826,0.0003193668,0.00002496543,0.000009942065,0.0004953273,0.00001691881,0.00004407037,0.9979472,0.00007472951,0.00004791701,0.0009066662],"study_design_scores_gemma":[0.0000699055,0.0005423861,0.02667569,0.00003127331,0.00008101334,0.006118892,0.00008354634,0.001343219,0.9599697,0.0002853215,0.004777368,0.00002158333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955115,0.0007536052,0.001620231,0.00009381137,0.0000369466,0.00002353424,0.0003870699,0.00012111,0.001452183],"genre_scores_gemma":[0.990554,0.001246064,0.002100612,0.0001106209,0.00001413443,0.00003518018,0.0009144423,0.00006616092,0.004958845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00183492,"threshold_uncertainty_score":0.006138444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340429038449444,"score_gpt":0.2723656149830943,"score_spread":0.2589613245985999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}