{"id":"W2061301855","doi":"10.1074/jbc.m110.107201","title":"Calnexin Deficiency Leads to Dysmyelination","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Calgary; University of Alberta","funders":"National Institute on Aging; National Science Foundation; Canadian Institutes of Health Research; U.S. Public Health Service; Multiple Sclerosis Society; Retina Research Foundation; Multiple Sclerosis Society of Canada; Alberta Innovates; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Heart and Stroke Foundation of Canada; March of Dimes Foundation","keywords":"Calnexin; Myelin; Biology; Cell biology; Central nervous system; Calreticulin; Endoplasmic reticulum; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002149456,0.00008847685,0.0001059843,0.0000185433,0.00003782108,0.00001677869,0.0001970605,0.0001888436,0.000199958],"category_scores_gemma":[0.0005942708,0.00006360451,0.0001133976,0.00007055868,0.00005846675,0.00000301706,0.00004827564,0.000153007,0.00001154023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007920074,"about_ca_system_score_gemma":0.00006386749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.755256e-7,"about_ca_topic_score_gemma":5.636754e-7,"domain_scores_codex":[0.9993429,0.00001597463,0.0002535083,0.0001361966,0.0001221386,0.0001292931],"domain_scores_gemma":[0.9993214,0.0000107511,0.0001332353,0.0001410653,0.0001839351,0.000209606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008000637,0.00007163901,0.01186492,0.000004807456,0.00000380313,0.000005008581,0.000004071612,0.00002535741,0.9850751,0.0000278891,0.001444792,0.001392656],"study_design_scores_gemma":[0.0004123213,0.0001850996,0.04495456,0.000005212682,0.000007861085,0.0001128068,0.00002457299,0.00001142398,0.9309816,0.0001632138,0.02300049,0.000140802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965433,0.0001190073,0.0007258797,0.0004638194,0.0001386751,0.00003503785,0.000005162371,0.000004877969,0.001964247],"genre_scores_gemma":[0.9976791,0.00001654094,0.001036264,0.0003216734,0.0005138098,0.00000163557,0.00001488742,0.000004958167,0.0004112026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05409342,"threshold_uncertainty_score":0.2593717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340429038449444,"score_gpt":0.2723656149830943,"score_spread":0.2589613245985999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}