{"id":"W2061303359","doi":"10.1139/bcb-78-3-217","title":"Function- and agonist-specific Ca&lt;sup&gt;2+&lt;/sup&gt; signalling: The requirement for and mechanism of spatial and temporal complexity in Ca&lt;sup&gt;2+&lt;/sup&gt; signals","year":2000,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Extracellular; Intracellular; Biology; Cytosol; Cell biology; Agonist; Function (biology); Signal transduction; Biophysics; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894262,0.0005097025,0.0007368343,0.0003710153,0.0002448817,0.0009055134,0.0005067197,0.0007069868,0.001781184],"category_scores_gemma":[0.0001684859,0.0001876625,0.0004521926,0.0004311771,0.000705508,0.001062319,0.0003926715,0.0009645752,0.001190719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004272934,"about_ca_system_score_gemma":0.0004206502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000512441,"about_ca_topic_score_gemma":0.0006346636,"domain_scores_codex":[0.9998833,0.00001283014,0.00001504401,0.00003194971,0.00003089846,0.00002598241],"domain_scores_gemma":[0.9999353,0.00001727859,0.00001569204,0.000005654109,0.00001423016,0.00001193119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004830456,0.00002980617,0.0004202937,0.00787929,0.00006535073,0.001901517,0.0002177012,0.001333197,0.8281934,0.04031702,0.004650045,0.1145093],"study_design_scores_gemma":[0.0000616705,0.0004630664,0.005160396,0.0004363731,0.0002018251,0.006034812,0.0003147883,0.002400581,0.3548638,0.02031077,0.6096546,0.00009741358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05784599,0.8870271,0.02912987,0.003811699,0.001398314,0.00006689828,0.0005383304,0.0003528154,0.01982885],"genre_scores_gemma":[0.2416986,0.7308715,0.00950393,0.001209853,0.001054422,0.00009924921,0.0008140131,0.00007628673,0.01467219],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001781184,"threshold_uncertainty_score":0.005958676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02449353707333629,"score_gpt":0.2361848539152494,"score_spread":0.2116913168419131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}